Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes
Título del documento: Decreased inflammatory response in rat bladder after intravesical administration of capsaicin-loaded liposomes
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000400490
ISSN: 0001-3765
Autors: 1
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Institucions: 1Universidade Tiradentes, Instituto de Tecnologia e Pesquisa, Aracaju, Sergipe. Brasil
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Període: Sep
Volum: 88
Número: 3
Paginació: 1539-1548
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés The objective of this work was to study the reduction in the capsaicin toxicity by encapsulation in liposomes. Capsaicin was extracted from peppers and characterized with high performance liquid chromatography (HPLC). We determined the zeta potential, polydispersivity index (PdI) and vesicle size of liposomes. Wistar rats were submitted to intravesical instillation of liposomes (LIP), capsaicin (CAP) or liposomes with capsaicin (CAPLIP). After 24 hours, bladders were removed for histological analysis. Vesicle size ranged from 68 to 105 nm with PdI smaller than 0.2 and zeta potential around -30 mV. The vesicles maintained stability over the 14-day study. The histological analysis of the CAP group showed intense inflammation in almost all bladder layers, as well as ulcer formation. Conversely, the CAPLIP group showed a smooth inflammatory reaction and hyperemia. In conclusion, the liposomes effectively protected the bladder against the irritative action of capsaicin
Disciplines Medicina,
Química
Paraules clau: Medicina experimental,
Química farmacéutica,
Capsaicina,
Respuesta inflamatoria,
Liposomas,
Incontinencia urinaria,
Ratas
Keyword: Medicine,
Chemistry,
Experimental medicine,
Medicinal chemistry,
Capsaicin,
Inflammatory response,
Liposomes,
Urinary incontinence,
Rats
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