Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.)
Título del documento: Chemical composition and evaluation of antileishmanial and cytotoxic activities of the essential oil from leaves of Cryptocarya aschersoniana Mez. (Lauraceae Juss.)
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000424346
ISSN: 0001-3765
Autors: 1
1
1
2
3
3
4
4
5
6
Institucions: 1Instituto Federal de Educacao, Ciencia e Tecnologia do Sul de Minas Gerais, Campus Pouso Alegre, Pouso Alegre, Minas Gerais. Brasil
2Instituto Federal de Educacao, Ciencia e Tecnologia do Sul de Minas Gerais, Campus Machado, Machado, Minas Gerais. Brasil
3Universidade de Franca, Centro de Pesquisa em Ciencias Exatas e Tecnologia, Franca, Sao Paulo. Brasil
4Universidade de Sao Paulo, Faculdade de Filosofia, Ciencias e Letras de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
5Instituto Federal de Educacao, Ciencia e Tecnologia Goiano, Campus Rio Verde, Rio Verde, Goias. Brasil
6Instituto Federal de Educacao Ciencia e Tecnologia do Triangulo Mineiro, Campus Uberlandia, Uberlandia, Minas Gerais. Brasil
Any:
Període: Sep
Volum: 90
Número: 3
Paginació: 2671-2678
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Leishmaniasis is an endemic disease caused by protozoa of the genus Leishmania, which affects around two million people worldwide. One major drawback in the treatment of leishmaniasis is the emergence of resistance to current chemotherapeutics. Medicinal and aromatic plants constitute a major source of natural organic compounds. In this study, the leaf essential oil of Cryptocarya aschersoniana was obtained by hydrodistillation in a Clevenger-type apparatus, and the chemical composition was analyzed by GC-MS and GC-FID. The essential oil of these species was predominantly constituted by monoterpene hydrocarbons (48.8%). Limonene (42.3%), linalool (9.7%) and nerolidol (8.6%) were the main constituents in the oil of C. aschersoniana. The in vitro activity of the oil was evaluated against the promastigote forms of Leishmania amazonensis, the causative agent of cutaneous leishmaniasis in humans. The essential oil of C. aschersoniana showed high activity against L. amazonensis promastigote forms (IC50 = 4.46 µg/mL), however, it also demonstrated a relatively high cytotoxicity on mouse peritoneal macrophages (CC50 = 7.71 µg/mL). This is the first report of the chemical composition and the leishmanicidal and cytotoxic activities of the leaf essential oil of C. aschersoniana
Disciplines Biología,
Química
Paraules clau: Fitoquímica,
Angiospermas,
Parasitología,
Aceites esenciales,
Composición química,
Cryptocarya aschersoniana,
Lauraceae,
Actividad citotóxica,
Leishmania amazonensis
Keyword: Phytochemistry,
Angiosperms,
Parasitology,
Essential oils,
Chemical composition,
Cryptocarya aschersoniana,
Lauraceae,
Cytotoxic activity,
Leishmania amazonensis
Text complet: Texto completo (Ver HTML)