| Revista: | Anais da Academia Brasileira de Ciencias |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000420590 |
| ISSN: | 0001-3765 |
| Autors: | Sousa-Neto, Benedito P1 Gomes, Bruno S1 Cunha, Francisco V.M1 Arcanjo, Daniel D.R1 Gutierrez, Stanley J.C1 Souza, Maria F.V2 Almeida, Fernanda R.C1 Oliveira, Francisco A1 |
| Institucions: | 1Universidade Federal do Piaui, Nucleo de Pesquisas em Plantas Medicinais, Teresina, Piaui. Brasil 2Universidade Federal da Paraiba, Centro de Ciencias da Saude, Joao Pessoa, Paraiba. Brasil |
| Any: | 2018 |
| Període: | Mar |
| Volum: | 90 |
| Número: | 1 |
| Paginació: | 185-194 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | The N-salicyloyltryptamine (NST) is an indole derivative compound analogue to the alkaloid N-benzoyltryptamine. In the present study, the antiedematogenic activity of NST was investigated in animal models. Firstly, the acute toxicity for NST was assessed according to the OECD Guideline no. 423. The potential NST-induced antiedematogenic activity was evaluated by carrageenan-induced paw edema in rats, as well as by dextran-, compound 48/80-, histamine-, serotonin-, capsaicine-, and prostaglandin E2-induced paw edema in mice. The effect of NST on compound 48/80-induced ex vivo mast cell degranulation on mice mesenteric bed was investigated. No death or alteration of behavioral parameters was observed after administration of NST (2000 mg/kg, i.p.) during the observation time of 14 days. The NST (100 and 200 mg/kg, i.p.) inhibited the carrageenan-induced edema from the 1st to the 5th hour (**p<0.01; ***p<0.001). The edematogenic activity induced by dextran, compound 48/80, histamine, serotonin, capsaicin, and prostaglandin E2 was inhibited by NST (100 mg/kg, i.p.) throughout the observation period (**p<0.01; ***p<0.001). The pretreatment with NST (50, 100 or 200 mg/kg, i.p) attenuates the compound 48/80-induced mast cell degranulation (**p<0.01; ***p<0.001). Thus, the inhibition of both mast cell degranulation and release of endogenous mediators are probably involved in the NST-induced antiedematogenic effect |
| Disciplines | Medicina, Química |
| Paraules clau: | Química farmacéutica, Antiinflamatorios, Indoles, Bioensayos, Modelos animales, N-saliciloiltriptamina |
| Keyword: | Medicinal chemistry, Antiinflammatory agents, Indoles, Bioassays, Animal models, N-salicyloyltryptamine |
| Text complet: | Texto completo (Ver HTML) |
