Activation of SOD-3 is involved in the antioxidant effect of a new class of β-aryl-chalcogenium azide compounds in Caenorhabditis elegans
Título del documento: Activation of SOD-3 is involved in the antioxidant effect of a new class of β-aryl-chalcogenium azide compounds in Caenorhabditis elegans
Revista: Anais da Academia Brasileira de Ciencias
Base de datos: PERIÓDICA
Número de sistema: 000436042
ISSN: 0001-3765
Autors: 1
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2
2
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1
Institucions: 1Universidade Federal do Pampa, Laboratorio de Bioquimica e Toxicologia em Caenorhabditis elegans, Uruguaiana, Rio Grande do Sul. Brasil
2Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul. Brasil
Any:
Volum: 92
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Experimental, aplicado
Resumen en inglés Organic selenium, tellurium and sulfur compounds have been studied due to their pharmacological properties. For instance, the β-aryl-chalcogenium azide compounds have demonstrated antitumoral action in vitro. However, yet no pharmacological actions of this class of compounds were determined in vivo. Caenorhabditis elegans is a nematode that presents innumerable advantages in relation to mammalian models, such as having a small and transparent body, which allows the visualization of its internal anatomy, besides short life and low cost. Based on that, the aim of this work was to investigate the pharmacological and toxicological properties of β-aryl-chalcogenium azide compounds in C. elegans. As well, to evaluate the capacity of organochalcogenium compounds to repair oxidative damage induced by hydrogen peroxide and the possible mechanism of action of these compounds using CF1553 transgenic strain with superoxide dismutase (SOD-3) tagged with GFP. Our results showed that β-aryl-chalcogenium azide have low toxicity in wild-type worms and the pre-treatment protected against the damage induced by hydrogen peroxide at higher tested concentration. Associated with this, we observed that this protection is due in part to the increased expression of the antioxidant enzyme SOD-3. In conclusion, β-aryl-chalcogenium azide compounds caused low toxicity and induced stress-resistance by modulating SOD-3 expression in C. elegans
Disciplines Medicina
Paraules clau: Farmacología,
Bioensayos,
Organochalcogénidos,
Selenio,
Estrés oxidativo,
Superóxido dismutasa,
Caenorhabditis elegans
Keyword: Pharmacology,
Bioassays,
Organochalcogenides,
Selenium,
Oxidative stress,
Superoxide dismutase,
Caenorhabditis elegans
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