Revista: | Anais brasileiros de dermatologia |
Base de datos: | PERIÓDICA |
Número de sistema: | 000427588 |
ISSN: | 0365-0596 |
Autores: | Luca, David Aldo De1 Enz, Paula Andrea1 Galimberti, Ricardo Luis1 Rinflerch, Adriana Raquel1 |
Instituciones: | 1Hospital Italiano de Buenos Aires, Departamento de Dermatología, Buenos Aires. Argentina |
Año: | 2018 |
Periodo: | Nov-Dic |
Volumen: | 93 |
Número: | 6 |
Paginación: | 913-915 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Nota breve o noticia |
Enfoque: | Analítico, descriptivo |
Resumen en inglés | The growth factor receptor c-kit (CD117) is expressed in immature T-cells and in some advanced forms of mycosis fungoides. c-kit gene mutation results in unrestricted neoplastic proliferation. We aimed to detect by PCR the most frequent exon mutations in seventeen plaque-stage MF patients, in their perilesional skin and in healthy skin donors. We secondarily evaluated CD117 expression by immunohistochemistry in plaque-stage and tumor-stage MF. We detected no mutation in c-kit gene and low CD117 expression was confirmed on atypical cells in one patient. Complete c-kit exon and intron sequences should be assessed and more sensitive sequencing method could be also applied |
Disciplinas: | Medicina |
Palabras clave: | Dermatología, Microbiología, Hongos, Micosis fungoide, Protooncogenes, Linfoma cutáneo, Células troncales |
Keyword: | Dermatology, Microbiology, Fungi, Mycosis fungoides, Protooncogenes, Cutaneous lymphoma, Stem cells |
Texto completo: | Texto completo (Ver HTML) |