No detection of c-kit gene mutations in exons 9, 11, 13 and 17 and low CD117 expression in plaque-stage mycosis fungoides
Título del documento: No detection of c-kit gene mutations in exons 9, 11, 13 and 17 and low CD117 expression in plaque-stage mycosis fungoides
Revista: Anais brasileiros de dermatologia
Base de datos: PERIÓDICA
Número de sistema: 000427588
ISSN: 0365-0596
Autors: 1
1
1
1
Institucions: 1Hospital Italiano de Buenos Aires, Departamento de Dermatología, Buenos Aires. Argentina
Any:
Període: Nov-Dic
Volum: 93
Número: 6
Paginació: 913-915
País: Brasil
Idioma: Inglés
Tipo de documento: Nota breve o noticia
Enfoque: Analítico, descriptivo
Resumen en inglés The growth factor receptor c-kit (CD117) is expressed in immature T-cells and in some advanced forms of mycosis fungoides. c-kit gene mutation results in unrestricted neoplastic proliferation. We aimed to detect by PCR the most frequent exon mutations in seventeen plaque-stage MF patients, in their perilesional skin and in healthy skin donors. We secondarily evaluated CD117 expression by immunohistochemistry in plaque-stage and tumor-stage MF. We detected no mutation in c-kit gene and low CD117 expression was confirmed on atypical cells in one patient. Complete c-kit exon and intron sequences should be assessed and more sensitive sequencing method could be also applied
Disciplines Medicina
Paraules clau: Dermatología,
Microbiología,
Hongos,
Micosis fungoide,
Protooncogenes,
Linfoma cutáneo,
Células troncales
Keyword: Dermatology,
Microbiology,
Fungi,
Mycosis fungoides,
Protooncogenes,
Cutaneous lymphoma,
Stem cells
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