| Revista: | Anais brasileiros de dermatologia |
| Base de datos: | |
| Número de sistema: | 000558044 |
| ISSN: | 0365-0596 |
| Autors: | Serra, Leonardo La1 Salathiel, Adriana Martinelli1 Lanaro, Rafael2 Martinis, Bruno de4 Roselino, Ana Maria1 |
| Institucions: | 1Universidade de São Paulo, Faculty of Medicine of Ribeirão Preto, Ribeirão Preto, São Paulo. Brasil 2Universidade Estadual de Campinas, Faculty of Medical Sciences, Campinas, São Paulo. Brasil 3Universidade Estadual de Campinas, Faculty of Pharmaceutical Sciences, Campinas, São Paulo. Brasil 4Universidade de São Paulo, Faculty of Philosophy Sciences and Letters of Ribeirão Preto, Ribeirão Preto, São Paulo. Brasil |
| Any: | 2023 |
| Volum: | 98 |
| Número: | 5 |
| Paginació: | 644-650 |
| País: | Brasil |
| Idioma: | Inglés |
| Resumen en inglés | Background Pesticides, mainly organophosphates (OP), have been related to increased risk of pemphigus vulgaris (PV) and pemphigus foliaceus (PF), nevertheless, their measurement has not been determined in pemphigus patients. Objective To evaluate pesticide exposure and pesticide measurement, comparing PV, PF and control groups in Southeastern Brazil. Methods Information about urban or rural residency and exposure to pesticides at the onset of pemphigus was assessed by questionnaire interview; hair samples from the scalp of PV, PF, and controls were tested for OP and organochlorines (OC) by gas-phase chromatography coupled to mass spectrometry. Results The minority of PV (2 7.1% of 28) and PF (7 18% of 39), but none of the 48 controls, informed living in rural areas at the onset of pemphigus (p = 0.2853). PV (33.3%), PF (38.5%), and controls (20%) informed exposure to pesticides (p = 0.186). Twenty-one (14.8%) of 142 individuals tested positive for OP and/or OC: PV (2 6.3% of 32) and PF (11 25.6% of 43) had similar pesticides contamination as controls (8 11.9% of 67) (p = 0.4928; p = 0.0753, respectively), but PF presented higher contamination than PV (p = 0.034). PV did not present any positivity for OP. Three (7%) PF tested positive for both OP and OC. Some PF tested positive for three or four OP, mainly diazinon and dichlorvos. Study limitation Lack of data for some controls. Conclusion Although the frequency of PV and PF patients exposed to pesticides was similar, pesticides were more frequently detected in hair samples from PF compared to PV. The cause-effect relationship still needs to be determined. |
| Keyword: | Diazinon, dichlorvos, Hydrocarbons, chlorinated, Organophosphate, Pemphigus, Pesticides |
| Text complet: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
