| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454210 |
| ISSN: | 0034-8376 |
| Autores: | Pérez Rubio, Gloria1 Córdoba Lanús, Elizabeth2 Cupertino, Paula3 Cartujano Barrera, Francisco3 Campos, Michael A4 Falfán Valencia, Ramcés1 |
| Instituciones: | 1Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Laboratorio de HLA, Ciudad de México. México 2Hospital Universitario Nuestra Señora de Candelaria, Unidad de Investigación, Santa Cruz de Tenerife, Canarias. España 3Hackensack University Medical Center, Department of Cancer Prevention Control, Hackensack, New Jersey. Estados Unidos de América 4University of Miami Health System, Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Miami, Florida. Estados Unidos de América |
| Año: | 2019 |
| Periodo: | Ene-Feb |
| Volumen: | 71 |
| Número: | 1 |
| Paginación: | 36-54 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality in developed countries. Although cigarette smoking is the major risk factor, only 10-20% of smokers develop COPD. The extent of cigarette smoking (pack-years and smoking duration) accounts for only 15% of the variation in lung function, indicating that differences in susceptibility to COPD must exist. We provide an overview of the complexity of nicotine addiction and COPD, with special attention to the involvement of genetic factors. The following aspects are discussed in the present article: (1) epidemiology in Mexico and (2) a review of the published literature on genetic association studies using the National Center for Biotechnology Information database of the United States as a search tool. COPD is unique among complex genetic diseases where an environmental risk factor is known and the level of exposure can be documented with some precision. The high morbidity and mortality associated with COPD and its chronic and progressive nature has prompted the use of molecular genetic studies to identify susceptibility factors for the disease. Biomedical research has a remarkable set of tools to aid in the discovery of genes and polymorphisms. We present a review of the most relevant genetic associations in nicotine addiction and COPD |
| Disciplinas: | Medicina |
| Palabras clave: | Neumología, Genética, Enfermedad pulmonar obstructiva crónica (EPOC), Exacerbación, Nicotina, Susceptibilidad genética, Polimorfismos de nucleótido único (SNPs) |
| Keyword: | Pneumology, Genetics, Chronic obstructive pulmonary disease (COPD), Exacerbation, Nicotine, Genetic susceptibility, Single nucleotide polymorphism (SNPs) |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
