Revista: | Annals of hepatology |
Base de datos: | PERIÓDICA |
Número de sistema: | 000406025 |
ISSN: | 1665-2681 |
Autores: | Pischke, Sven1 Schulze-zur-Wiesch, Julian1 Lütgehetmann, Marc2 Kreuels, Benno1 Lueth, Stefan1 Kapaun, Petra1 Benten, Daniel1 Schmiedel, Stefan1 Sterneck, Martina1 Lohse, Ansgar W1 Polywka, Susanne3 |
Instituciones: | 1University Medical Center Hamburg-Eppendorf, Department of Medicine, Hamburgo. Alemania 2German Center for Infection Research, Hamburgo. Alemania 3University Medical Center Hamburg-Eppendorf, Institute for Microbiology, Hamburgo. Alemania |
Año: | 2017 |
Periodo: | Ene-Feb |
Volumen: | 16 |
Número: | 1 |
Paginación: | 57-57 |
País: | México |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Aplicado |
Resumen en inglés | There are only few reports about travel-associated, imported tropical hepatitis E virus (HEV) genotype 1 infections within Western travellers. We describe the clinical course of a single outbreak of hepatitis E in a German travellers group returning from India and compare the results of two commercial HEV-seroassays. Material and methods. After identifying hepatitis E in an index patient returning from a journey to India all 24 members of this journey were tested for anti-HEV-IgG and IgM using two commercial seroassays (Wantai and Mikrogen), for HEV-RNA by PCR and HEV-Ag by an antigen-assay (Wantai). Results. 5/24 (21%) individuals were viraemic with viral loads between 580-4,800,000 IU/mL. Bilirubin and ALT levels in these patients ranged from 1.3-14.9 mg/dL (mean 7.3 mg/dL, SD 5.6 mg/dL) and 151-4,820 U/L (mean 1,832U/L, SD 1842U/L), respectively and showed significant correlations with viral loads (r = 0.863, p < 0.001; r = 0.890, p < 0.001). No risk factor for food-borne HEV-transmission was identified. All viraemic patients (5/5) tested positive for anti-HEV-IgG and IgM in the Wantai-assay but only 4/5 in the Mikrogen-assay. Wantai-HEV-antigen-assay was negative in all patients. Six months later all previously viraemic patients tested positive for anti-HEV-IgG and negative for IgM in both assays. However, two non-viremic individuals who initially tested Wantai-IgM-positive stayed positive indicating false positive results. Conclusions. Despite the exact number of exposed individuals could not be determined HEV genotype 1 infections have a high manifestation rate of more than 20%.The Wantai-antigen-test failed, the Wantai-IgMrapid-test and the Mikrogen-IgM-recomblot showed a better performance but still they cannot replace real-time PCR for diagnosing ongoing HEV-infections |
Disciplinas: | Medicina |
Palabras clave: | Diagnóstico, Gastroenterología, Salud pública, Hepatitis E, Infecciones, Viajeros, Serología, Manifestaciones clínicas, Pruebas diagnósticas |
Keyword: | Medicine, Diagnosis, Gastroenterology, Public health, Hepatitis E, Infections, Travelers, Serology, Clinical manifestations, Diagnostic tests |
Texto completo: | Texto completo (Ver HTML) |