| Revue: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000420032 |
| ISSN: | 0074-0276 |
| Autores: | Santos, André Luis Souza dos1 Galdino, Anna Clara Milesi1 Mello, Thaís Pereira de1 Ramos, Lívia de Souza1 Branquinha, Marta Helena1 Bolognese, Ana Maria2 Columbano Neto, José3 Roudbary, Maryam4 |
| Instituciones: | 1Universidade Federal do Rio de Janeiro, Instituto de Microbiologia "Paulo de Goes", Rio de Janeiro. Brasil 2Universidade Federal do Rio de Janeiro, Faculdade de Odontologia, Rio de Janeiro. Brasil 3Faculdades Sao Jose, Faculdade de Odontologia, Rio de Janeiro. Brasil 4Iran University of Medical Sciences, School of Medicine, Teherán. Irán |
| Año: | 2018 |
| Volumen: | 113 |
| Número: | 9 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Biofilm formation is the preferred mode of growth lifestyle for many microorganisms, including bacterial and fungal human pathogens. Biofilm is a strong and dynamic structure that confers a broad range of advantages to its members, such as adhesion/cohesion capabilities, mechanical properties, nutritional sources, metabolite exchange platform, cellular communication, protection and resistance to drugs (e.g., antimicrobials, antiseptics, and disinfectants), environmental stresses (e.g., dehydration and ultraviolet light), host immune attacks (e.g., antibodies, complement system, antimicrobial peptides, and phagocytes), and shear forces. Microbial biofilms cause problems in the hospital environment, generating high healthcare costs and prolonged patient stay, which can result in further secondary microbial infections and various health complications. Consequently, both public and private investments must be made to ensure better patient management, as well as to find novel therapeutic strategies to circumvent the resistance and resilience profiles arising from biofilm-associated microbial infections. In this work, we present a general overview of microbial biofilm formation and its relevance within the biomedical context |
| Disciplinas: | Medicina, Biología |
| Palabras clave: | Microbiología, Biopelículas, Microorganismos, Patógenos, Adhesión microbiana, Virulencia |
| Keyword: | Microbiology, Biofilms, Microorganisms, Pathogens, Microbial adhesion, Virulence |
| Texte intégral: | Texto completo (Ver HTML) |
