| Revue: | Memorias do Instituto Oswaldo Cruz |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000420026 |
| ISSN: | 0074-0276 |
| Autores: | Silveira, Melise Chaves1 Catanho, Marcos2 Miranda, Antônio Basílio de1 |
| Instituciones: | 1Instituto Oswaldo Cruz, Laboratorio de Biologia Computacional e Sistemas, Rio de Janeiro. Brasil 2Instituto Oswaldo Cruz, Laboratorio de Genomica Funcional e Bioinformatica, Rio de Janeiro. Brasil |
| Año: | 2018 |
| Volumen: | 113 |
| Número: | 8 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | β-lactamases, which are found in several bacterial species and environments, are the main cause of resistance to β-lactams in Gram-negative bacteria. In 2009, a protein (LRA-13) with two β-lactamase domains (one class C domain and one class D domain) was experimentally characterised, and an extended action spectrum against β-lactams consistent with two functional domains was found. Here, we present the results of searches in the non-redundant NCBI protein database that revealed the existence of a group of homologous bifunctional β-lactamases in the genomes of environmental bacteria. These findings suggest that bifunctional β-lactamases are widespread in nature; these findings also raise concern that bifunctional β-lactamases may be transferred to bacteria of clinical importance through lateral gene transfer mechanisms |
| Disciplinas: | Medicina |
| Palabras clave: | Genética, Bacterias, Resistencia bacteriana, Análisis genómico, Beta-lactamasa |
| Keyword: | Genetics, Bacteria, Bacterial resistance, Genomic analysis, Beta-lactamase |
| Texte intégral: | Texto completo (Ver HTML) |
