| Revue: | Anais brasileiros de dermatologia |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000427560 |
| ISSN: | 0365-0596 |
| Autores: | Silvestre, Marilene Chaves1 Reis, Vitor Manoel Silva dos2 |
| Instituciones: | 1Universidade Federal de Goias, Departamento de Medicina Tropical e Dermatologia, Goiania, Goias. Brasil 2Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil |
| Año: | 2018 |
| Periodo: | Nov-Dic |
| Volumen: | 93 |
| Número: | 6 |
| Paginación: | 829-835 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en inglés | Allergic contact dermatitis to ion nickel (Ni+2) is an inflammatory dermatosis, common in industrialized countries. It involves the activation of nickel-specific T-cells, followed by proliferation and induction of a mixed profile of both proinflammatory and regulatory cytokines, suggesting that several T-cell subtypes (helper - Th and cytotoxic - Tc) are involved. A broader understanding of the cytokine profile may lead to new therapeutic approaches. Objectives: This study aimed to analyze the cytokines TNF-α, INF-γ, IL-2, IL-4, IL-10, IL-13, IL-17 and IL-23 using the immunohistochemistry technique in order to try to identify their prevalence in chronic and acute eczema of patients with allergic contact dermatitis to Ni+2. Methods: We performed an immunohistochemical study for eight cytokines in 20 patients with Ni+2 allergic contact dermatitis, biopsied at the site of chronic eczema, triggered by the patient's daily contact with Ni+2, and at the site of acute eczema caused by nickel sulfate, 48 hours after applying the contact test. Results: The stained samples showed positive results for the eight cytokines studied. TNF-α, IFN-γ, IL-4, IL-13 and IL-17 had a higher prevalence in chronic eczema, IL-2 and IL-23 in acute eczema, and IL-10 presented a similar prevalence in both acute and chronic eczema. However, these prevalences were statistically significant only for IL-4 and IL-13. Study Limitations: Small sample size. Conclusions: In chronic and acute eczema, we observed the presence of a mixed cytokine profile of the T cell subtypes (Th/Tc), suggesting that the responses are expressed at the same time |
| Disciplinas: | Medicina |
| Palabras clave: | Dermatología, Inmunología, Dermatitis de contacto, Níquel, Alergia, Citocinas, Inmunohistoquímica |
| Keyword: | Dermatology, Immunology, Contact dermatitis, Nickel, Allergy, Cytokines, Immunohistochemistry |
| Texte intégral: | Texto completo (Ver HTML) |
