| Revista: | Genetics and molecular biology |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000418065 |
| ISSN: | 1415-4757 |
| Autores: | Fagundes, Nelson J.R1 Tagliani-Ribeiro, Alice2 Rubicz, Rohina3 Tarskaia, Larissa4 Crawford, Michael H4 Salzano, Francisco M1 Bonatto, Sandro L5 |
| Instituciones: | 1Universidade Federal do Rio Grande do Sul, Departamento de Genetica, Porto Alegre, Rio Grande do Sul. Brasil 2Pontificia Universidade Catolica do Rio Grande do Sul, Centro Clinico, Porto Alegre, Rio Grande do Sul. Brasil 3Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington. Estados Unidos de América 4University of Kansas, Laboratory of Biological Anthropology, Lawrence, Kansas. Estados Unidos de América 5Pontificia Universidade Catolica do Rio Grande do Sul, Faculdade de Biociencias, Porto Alegre, Rio Grande do Sul. Brasil |
| Año: | 2018 |
| Periodo: | Mar |
| Volumen: | 41 |
| Paginación: | 206-214 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico |
| Resumen en inglés | In spite of many genetic studies that contributed for a deep knowledge about the peopling of the Americas, no consensus has emerged about important parameters such as the effective size of the Native Americans founder population. Previous estimates based on genomic datasets may have been biased by the use of admixed individuals from Latino populations, while other recent studies using samples from Native American individuals relied on approximated analytical approaches. In this study we use resequencing data for nine independent regions in a set of Native American and Siberian individuals and a full-likelihood approach based on isolation-with-migration scenarios accounting for recent flow between Asian and Native American populations. Our results suggest that, in agreement with previous studies, the effective size of the Native American population was small, most likely in the order of a few hundred individuals, with point estimates close to 250 individuals, even though credible intervals include a number as large as ~4,000 individuals. Recognizing the size of the genetic bottleneck during the peopling of the Americas is important for determining the extent of genetic markers needed to characterize Native American populations in genome-wide studies and to evaluate the adaptive potential of genetic variants in this population |
| Disciplinas: | Demografía, Biología |
| Palabras clave: | Características de la población, Genética, Censos y estadísticas, Aislamiento, Modelos de migración, Análisis coalescente, Siberianos nativos |
| Keyword: | Demographics, Genetics, Census and statistics, Isolation, Migration model, Coalescent analysis, Native Siberians |
| Texto completo: | Texto completo (Ver PDF) |
