| Journal: | Revista médica de Chile |
| Database: | PERIÓDICA |
| System number: | 000423874 |
| ISSN: | 0034-9887 |
| Authors: | Querales, Marvin Isaac1 Cruces, María Elena1 Rojas, Susan1 |
| Institutions: | 1Universidad de Carabobo, Escuela de Bioanálisis, Valencia, Carabobo. Venezuela |
| Year: | 2019 |
| Season: | Oct |
| Volumen: | 147 |
| Number: | 10 |
| Pages: | 1312-1318 |
| Country: | Chile |
| Language: | Español |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Vitamin D has an essential role in calcium metabolism and bone health. Vitamin D3 or cholecalciferol is synthesized from 7-dehydrocholesterol or provitamin D3, by sunlight ultraviolet radiation to the skin. 7-dehydrocholesterol is subsequently hydroxylated in the liver and then in the kidney to produce 1,25-(OH)2D3, the active metabolite that binds to specific receptors (VDR) in target tissues, mainly bone and intestine. Other tissues, such as the immune and cardiovascular system, have also VDR. Vitamin D deficiency can induce rickets in children and osteomalacia and osteoporosis in adults. A possible inverse association between vitamin D levels and the prevalence of metabolic syndrome has been proposed. Vitamin D deficiency increases the risk of type 1 diabetes, insulin resistance, and hypertension, key components of this syndrome. However, other studies have not confirmed this association. Further clinical and experimental studies are needed to ascertain the role of vitamin D in metabolic syndrome |
| Disciplines: | Química, Medicina |
| Keyword: | Bioquímica, Metabolismo y nutrición, Endocrinología, Resistencia a la insulina, Vitamina D, Síndrome metabólico |
| Keyword: | Biochemistry, Metabolism and nutrition, Endocrinology, Insulin resistance, Vitamin D, Metabolic syndrome |
| Full text: | Texto completo (Ver PDF) |
