| Revista: | Revista de investigación clínica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000454099 |
| ISSN: | 0034-8376 |
| Autores: | Zeeshan Haider, Rana1 Urrechaga, Eloisa2 Uddin Ujjan, Ikram3 Sultan Shamsi, Tahir1 |
| Instituciones: | 1National Institute of Blood Disease and Bone Marrow Transplantation, Karachi, Baluchistán. Pakistán 2Hospital Galdakao-Usansolo, Laboratorio de Hematología, Galdácano, Vizcaya. España 3Liaquat University of Medical and Health Science, Basic Medical Sciences, Jamshoro. Pakistán |
| Año: | 2020 |
| Periodo: | Ene-Feb |
| Volumen: | 72 |
| Número: | 1 |
| Paginación: | 37-45 |
| País: | México |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Aplicado, descriptivo |
| Resumen en inglés | Background: The hematology analyzer, Sysmex XN-1000, generates white blood cell count with varying scattering intensities during a complete blood count (CBC) analysis. Objectives: The objectives of the study were to study the predictive role of median and coefficient of variation of neutrophil scattering items in blood samples for differentiation of leukemic subjects. Methods: We evaluated six neutrophil scattering parameters: neutrophil side scatter mean intensity, neutrophil side fluorescence light (SFL) mean intensity, neutrophil forward scatter mean intensity, neutrophil side scatter area distribution width (NE-WX), neutrophil SFL area distribution width (NE-WY), and neutrophil forward scatter area distribution width (NE-WZ), measured in white blood cell differential scattergram generated by the hematology analyzer (Sysmex XN-1000) at an academic medical center. Results: We collected 433 blood samples from acute myeloid leukemia (AML) and acute lymphoid leukemia (ALL) cases and normal controls. AML group showed highly significant differences in the mean values compared with the control group. Out of six neutrophil scattering items, NE-WX, NE-WY, and NE-WZ showed high efficiency, with area under the curve (AUC) values of 0.764, 0.748, and 0.757, respectively, to differentiate AML from ALL cases and control groups. When comparing combined acute leukemia cases (AML plus ALL) with the control group, NE-WX, NE-WY, and NE-WZ generated highly significant AUC values (0.840, 0.884, and 0.801, respectively). Conclusion: The neutrophil scattering parameters generated during CBC analysis provide a new tool for the prediction of acute leukemia and its lineage |
| Disciplinas: | Medicina |
| Palabras clave: | Hematología, Oncología, Diagnóstico, Leucemia aguda, Analizadores hematológicos, Dispersión de neutrófilos |
| Keyword: | Hematology, Oncology, Diagnosis, Acute leukemia, Hematological analyzers, Neutrophil scattering |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
