Health-Related Quality of Life in leukemia Survivors of Allogeneic Hematopoietic Stem Cell Transplantation Employing the Mexican Reduced-Intensity Conditioning



Document title: Health-Related Quality of Life in leukemia Survivors of Allogeneic Hematopoietic Stem Cell Transplantation Employing the Mexican Reduced-Intensity Conditioning
Journal: Revista de investigación clínica
Database: PERIÓDICA
System number: 000390742
ISSN: 0034-8376
Authors: 1
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4
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1
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2
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Institutions: 1Clínica Ruiz de Puebla, Centro de Hematología y Medicina Interna, Puebla. México
2Universidad de las Américas, Puebla. México
3Universidad Autónoma de Nuevo León, Hospital Universitario Dr. José Eleuterio González, Monterrey, Nuevo León. México
4Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, Distrito Federal. México
5Universidad Popular Autónoma del Estado de Puebla, Puebla. México
Year:
Season: Mar-Abr
Volumen: 67
Number: 2
Pages: 109-116
Country: México
Language: Inglés
Document type: Estadística o encuesta
Approach: Analítico
English abstract Quality of life (QOL) is an important consideration in the counseling, implementation, and post-treatment management of arduous treatments for life-threatening conditions such as allogeneic hematopoietic cell transplantation (allo-HCT). Objective: To analyze the QOL of leukemia patients allografted with the Mexican reduced-intensity conditioning regimen in two Mexican academic medical centers. Material and methods: By means of the quality metric short form 36 version 2 to measure generic health concepts, relevant QOL was analyzed in leukemia patients who underwent allo-HCT using reducedintensity conditioning on an outpatient basis at either the Centro de Hematología y Medicina Interna de Puebla of the Clínica Ruiz or the Hematology Service of the Internal Medicine Department of the Hospital “Dr. José Eleuterio González” of the Universidad Autónoma de Nuevo León, and who had survived more than 12 months after the allograft, who could be approached, who were in a continued complete remission (with or without graft-versus-host disease), and who were willing to respond to the questionnaire. Thirty-five patients fulfilling these requirements were included, and a sex- and age-matched group of 35 reference subjects was also studied. Results: Allografted patients were found to have a slightly better mental component summary than the reference subjects (53.23 vs. 48.66 points; p = 0.01), whereas the physical component summary did not show a difference (54.53 vs. 52.05 points; p = 0.59). Most of the differences between allografted individuals and reference subject controls were not significant. Conclusions: Despite several sources of bias, these data suggest that allografted individuals employing the Mexican reduced-intensity conditioning regimen enjoy a health-related QOL life similar to that of reference subjects, adding another advantage of this method of conducting stem cell allografts. However
Disciplines: Medicina
Keyword: Oncología,
Salud pública,
Calidad de vida,
Salud,
Trasplantes,
Células madre hematopoyéticas,
Leucemia,
Aloinjertos
Keyword: Medicine,
Oncology,
Public health,
Quality of life,
Health,
Transplantation,
Hematopoietic stem cells,
Leukemia,
Allografts
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