Journal: | Journal of the Mexican Chemical Society |
Database: | PERIÓDICA |
System number: | 000411953 |
ISSN: | 1665-9686 |
Authors: | Ekengard, Erik1 Bergare, Ida1 Hansson, Josefine1 Doverbratt, Isa1 Monari, Magda2 Gordhan, Bhavna3 Kana, Bavesh3 Kock, Carmen de4 Smith, Peter J4 Nordlander, Ebbe1 |
Institutions: | 1Lund University, Department of Chemistry, Lund, Malmohus. Suecia 2Universita di Bologna, Dipartimento di Chimica “G. Ciamician”, Bolonia, Emilia Romaña. Italia 3University of the Witwatersrand, Faculty of Health Sciences, Johannesburgo, Transvaal. Sudáfrica 4University of Cape Town, Medical School, Cape Town. Sudáfrica |
Year: | 2017 |
Season: | Abr-Jun |
Volumen: | 61 |
Number: | 2 |
Pages: | 158-166 |
Country: | México |
Language: | Inglés |
Document type: | Artículo |
Approach: | Experimental, analítico |
Spanish abstract | La síntesis y caracterización de N-(2-(7-cloroquinolin-4-il) amino)etil)pirazina-2-carboxamida (L), un híbrido de aminoquinolina-pirazinamida, y los complejos hexafluorofosfato de N-(2-cloroquinolin-4-il)amino)etil)pirazina-2-carboxamida)(ciclopentadienil) clorido rodio o iridio ([M(L)(Cp*)Cl] PF6; M = Rh, Ir) También see describen las sales de cloruro ([M(L)(Cp*) Cl] Cl; M = Rh, Ir). Se evaluó las actividades anti-plasmodial y anti-microbacteriana del ligante y de las sales de hexafluorofosfato de los complejos metálicos. Los complejos de rodio y de iridio eran significativamente más activos contra M. tuberculosis que el ligante libre. Las estructuras moleculares de los complejos (hexafluorofosfato de N-(2-((7-cloroquinolin-4-il) amino)etil)pirazina-2-carboxamida)(ciclopentadienil) cloro-rodio y cloruro de (N-(2-cloroquinolin-4-il)amino)etil) pirazina-2-carboxamida)(ciclopentadienil)cloro-iridio se resolvieron cristalográficamente |
English abstract | The synthesis and characterization of N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide (L), an aminoquinoline - pyrazinamide hybrid, and the complexes (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl)chlorido-rhodium or iridium hexafluorophosphate ([M(L)(Cp*)Cl]PF6; M = Rh, Ir) and the corresponding chlorido salts ([M(L)(Cp*)Cl]Cl; M = Rh, Ir) are described. The ligand and the hexafluorophosphate salts of the metal complexes have been evaluated for anti-plasmodial and anti-mycobacterial activity. The rhodium and the iridium complexes were significantly more active against M. tuberculosis than the free ligand. The crystallographically determined molecular structures of complexes (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl)chlororhodium hexafluoro-phosphate and (N-(2-((7-chloroquinolin-4-yl)amino)ethyl)pyrazine-2-carboxamide)(cyclopentadienyl)chloro-iridium chloride are presented |
Disciplines: | Química |
Keyword: | Química farmacéutica, Tuberculosis, Compuestos organometálicos, Cloroquina, Pirazinamida |
Keyword: | Chemistry, Medicinal chemistry, Malaria, Organometallic compounds, Chloroquine, Pyrazinamide |
Full text: | Texto completo (Ver HTML) |