| Journal: | Genetics and molecular biology |
| Database: | PERIÓDICA |
| System number: | 000408500 |
| ISSN: | 1415-4757 |
| Authors: | Domitrovic, Tatiana1 Fausto, Anna K1 Silva, Tatiane da F2 Romanel, Elisson2 Vaslin, Maite F.S1 |
| Institutions: | 1Universidade Federal do Rio de Janeiro, Departamento de Virologia, Rio de Janeiro. Brasil 2Universidade de Sao Paulo, Escola de Engenharia de Lorena, Lorena, Sao Paulo. Brasil |
| Year: | 2017 |
| Volumen: | 40 |
| Pages: | 253-260 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Regulation of protein stability and/or degradation of misfolded and damaged proteins are essential cellular processes. A part of this regulation is mediated by the so-called N-end rule proteolytic pathway, which, in concert with the ubiquitin proteasome system (UPS), drives protein degradation depending on the N-terminal amino acid sequence. One important enzyme involved in this process is arginyl-t-RNA transferase, known as ATE. This enzyme acts post-translationally by introducing an arginine residue at the N-terminus of specific protein targets to signal degradation via the UPS. However, the function of ATEs has only recently begun to be revealed. Nonetheless, the few studies to date investigating ATE activity in plants points to the great importance of the ATE/N-end rule pathway in regulating plant signaling. Plant development, seed germination, leaf morphology and responses to gas signaling in plants are among the processes affected by the ATE/N-end rule pathway. In this review, we present some of the known biological functions of plant ATE proteins, highlighting the need for more in-depth studies on this intriguing pathway |
| Disciplines: | Biología |
| Keyword: | Botánica, Fisiología vegetal, Bioquímica vegetal, Degradación protéica, Sistema proteasoma ubiquitina, Arginiltransferasas |
| Keyword: | Biology, Botany, Plant physiology, Plant biochemistry, Protein degradation, Ubiquitin proteasome system, Arginyltransferases |
| Full text: | Texto completo (Ver HTML) |
