Viral Outcome in Patients with Occult HBV Infection or HCV-Ab Positivity Treated for Lymphoma



Document title: Viral Outcome in Patients with Occult HBV Infection or HCV-Ab Positivity Treated for Lymphoma
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000409332
ISSN: 1665-2681
Authors: 1
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Institutions: 1Universita di Napoli "Federico II", Dipartimento di Medicina Clinica, Nápoles, Campania. Italia
Year:
Season: Mar-Abr
Volumen: 16
Number: 2
Pages: 198-206
Country: México
Language: Inglés
Document type: Estadística o encuesta
Approach: Analítico
English abstract HBV and HCV reactivation has been widely reported in patients undergoing immunosuppressive therapy for oncohaematological diseases. We aimed to evaluate the HBV and HCV reactivation events in patients with non-Hodgkin lymphoma (NHL) or Hodgkin lymphoma (HL) underwent cytotoxic chemotherapy containing or not rituximab. This is a retrospective observational study, including all patients with NHL and HL attending an Italian tertiary referral hospital, the University of Naples “Federico II”. A total of 322 patients were enrolled. We evaluated serum HBV and HCV markers. A total of 47 (38%) patients with occult HBV infection were enrolled. Seven/47 were treated with therapeutic cytotoxic schedule containing rituximab. Of them, 6/7 received prophylaxis with lamivudine. HBV reactivation was observed in two patients treated with rituximab. A reactivation was observed in the only patient (HBcAb+/HBsAb+) not receiving lamivudine prophylaxis, and the other one was observed in 1 patient with isolated HBcAb positivity during lamivudine prophylaxis. Moreover, 8 patients with HCV-Ab positivity were enrolled. No viral reactivation was observed in these patients. In conclusion, patients with occult HBV infection receiving chemotherapy containing rituximab for lymphoma without antiviral prophylaxis are at risk of viral reactivation. On the contrary, there is no risk of reactivation in patients undergoing rituximab-free schedule. Our findings suggest that there is also very low risk of HCV reactivation. This preliminary report underlines the concept that HBV reactivation is strongly related to the type of immunosuppressive therapy administered and that antiviral prophylaxis needs to be tailored
Disciplines: Medicina
Keyword: Gastroenterología,
Oncología,
Inmunología,
Rituximab,
Quimioterapia,
Infección oculta,
Hepatitis B,
Hepatitis C,
Profilaxis,
Reactivación
Keyword: Medicine,
Gastroenterology,
Oncology,
Immunology,
Rituximab,
Chemotherapy,
Occult infection,
Hepatitis B,
Hepatitis C,
Prophylaxis,
Reactivation
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