| Journal: | Anais brasileiros de dermatologia |
| Database: | PERIÓDICA |
| System number: | 000410441 |
| ISSN: | 0365-0596 |
| Authors: | Montagna, Erik1 Lopes, Otavio Sergio2 |
| Institutions: | 1Faculdade de Medicina do ABC, Santo Andre, Sao Paulo. Brasil 2Santa Casa de Sao Paulo, Faculdade de Ciencias Medicas, Sao Paulo. Brasil |
| Year: | 2017 |
| Season: | Jul-Ago |
| Volumen: | 92 |
| Number: | 4 |
| Pages: | 517-520 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Basal cell carcinoma is the most common cancer, presenting low mortality but high morbidity, and it has as risk factor exposure to sunlight, especially UVB spectrum. The most important constitutional risk factors for basal cell carcinoma development are clear phototypes (I and II, Fitzpatrick classification), family history of basal cell carcinoma (30-60%), freckles in childhood, eyes and light hair. The environmental risk factor better established is exposure to ultraviolet radiation. However, different solar exposure scenarios probably are independent risk factors for certain clinical and histological types, topographies and prognosis of this tumor, and focus of controversy among researchers. Studies confirm that changes in cellular genes Hedgehog signaling pathway are associated with the development of basal cell carcinoma. The cellular Hedgehog signaling pathway is activated in organogenesis, but is altered in various types of tumors |
| Disciplines: | Medicina |
| Keyword: | Dermatología, Oncología, Cáncer, Piel, Carcinoma basocelular, Factores de riesgo, Factores genéticos, Proteínas |
| Keyword: | Medicine, Dermatology, Oncology, Cancer, Skin, Basal cell carcinoma, Risk factors, Genetic factors, Proteins |
| Full text: | Texto completo (Ver HTML) |
