Analysing the antidepressant and drug efflux competence of Clitoria ternateaL. as P-glycoprotein inhibitor to facilitate blood brain barrier



Título del documento: Analysing the antidepressant and drug efflux competence of Clitoria ternateaL. as P-glycoprotein inhibitor to facilitate blood brain barrier
Revista: Acta scientiarum. Biological sciences
Base de datos: PERIÓDICA
Número de sistema: 000433543
ISSN: 1679-9283
Autors: 1
1
2
2
Institucions: 1Bishop Heber College, Department of Biotechnology and Bioinformatics, Tiruchirapalli, Tamil Nadu. India
2Bharathidasan University, School of Life Sciences, Tiruchirapalli, Tamil Nadu. India
Any:
Volum: 41
País: Brasil
Idioma: Inglés
Tipo de documento: Artículo
Enfoque: Analítico, descriptivo
Resumen en inglés Clitoria ternateaL. is a vital ayurvedic herbfeatured with a wide spectrum of mental health benefits. The present study investigates the competence of the plant against depression and to inhibit the membrane efflux protein P-glycoprotein (P-gp) that can regulate and restrict drug permeation into the brain. Antidepressant competence of the aqueous plant extract was assessed by animal despair studies on depression induced female mice models. The P-glycoprotein inhibitory potential of active phytocompounds was evaluated by molecular docking assay and substantiated by a cell line study. The in vivostudies exhibited a significant difference in the immobility time thereby establishing antidepressant activity. The histopathological sections from cortex region of treated brain showed decreased degenerative changes. Ten imperative phytocompounds facilitated docking complexes against P-glycoprotein among which Kaempferol 3-O-(2״,6״-di-O-rhamnopyranosyl) glucopyranoside exhibited a finest docking score of -12.569 kcal mol-1. Conversely it was attested by the rhodamine transport assay that demonstrated the inhibitory potential to surpass blood brain barrier. The outcome of the study endorses the efficacy of Clitoria ternateaL. as an idyllic brain drug and facilitates brain permeability
Disciplines Biología,
Medicina
Paraules clau: Química farmacéutica,
Psiquiatría,
Angiospermas,
Plantas medicinales,
Depresión,
Flujo de membrana,
Glucoproteínas,
Permeabilidad cerebral,
Clitoria ternatea,
Papilionaceae
Keyword: Medicinal chemistry,
Psychiatry,
Angiosperms,
Medicinal plants,
Depression,
Membrane flux,
Glycoproteins,
Brain permeability,
Clitoria ternatea,
Papilionaceae
Text complet: http://periodicos.uem.br/ojs/index.php/ActaSciBiolSci/article/view/46629/751375149051