Mas allá de la prevención primaria: utilidad de la proteína C reactiva ultra sensible (PCRus), como herramienta en el diagnóstico de enfermedad arterial coronaria



Título del documento: Mas allá de la prevención primaria: utilidad de la proteína C reactiva ultra sensible (PCRus), como herramienta en el diagnóstico de enfermedad arterial coronaria
Revista: Síndrome cardiometabólico
Base de datos: PERIÓDICA
Número de sistema: 000346507
ISSN: 2244-7261
Autores: 1
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Instituciones: 1Hospital Militar "Dr. Carlos Arvelo", Caracas, Distrito Federal. Venezuela
Año:
Volumen: 1
Número: 2
Paginación: 40-44
País: Venezuela
Idioma: Español
Tipo de documento: Artículo
Enfoque: Aplicado, analítico
Resumen en español positiva, por lo que fueron llevados a laboratorio de hemodinamia resultando todos con enfermedad arterial coronaria. Conclusion: En pacientes con 2 o mas factores de riesgo para EAC, la PCRus podría ser considerada como factor predictor de ateroesclerosis coronario sobre todo si es relacionado con fibrinógeno > 350 mg/dl y LDLc > 100 mg/dl. La misma podría ser una herramienta útil en la escogencia de pacientes con alto riesgo para ser llevados a realización de CCG y de esta forma disminuir la morbi mortalidad cardiovascular, el número de eventos con Síndromes Coronarios agudos (SCA), y más aún instaurar e intensificar medidas de tratamiento en pacientes de riesgo antes de que aparezcan las complicaciones
Resumen en inglés The C-reactive protein (CRP) is an acute phase, highly sensitive phase general inflammation marker protein. In adults, the PCR, detected with ultra-sensitive techniques (PCRus), is associated with the traditional risk factors and its concentration predicts cardiovascular events. The objective of this study was to assess the usefulness of the protein C reactive (PCRus) as a tool for the diagnosis of Coronary Arterial Disease (CAD). A group of 37 patients from the Arterial Hypertension Unit of the military hospital Dr. Carlos Arvelo presenting 3 or more risk factors (RF) and no history of CDA were evaluated for glucose, total cholesterol, HDLc and LDLc, triglycerides, fibrinogen, and PCRus using a PATHFAT Analyzer. They were also subjected to transthoracic echocardiogram (TTE), two-dimensional stress test (ST) using a bruce protocol, and an echo stress with Dobutamine where the patients exhibiting positive results were further submitted to an angiography. Results: The patients had an average age of 60.54 ±5 years, 59.45% of which were male and 40.55% female. They exhibited the following characteristics: 100% hypertensive; 21.62% diabetics; 59.45% smokers; and 48.64% dyslipidemic. Further, 27.27% of the male population presented HDLc levels below 40 mg/ dl while 33.33% female population showed levels below 50 mg/dl; 75.67% of patients of both sexes presented LDLc > 100 m/dl; 40.54% were obese; 51.37% were sedentary; Fibrinogen > 350 mg/dl in 54.06%, corresponds to PCR us > 1 mg/l of 75.67%. Those who had PCRus > 2.6 mg/l represented 40.55% of the total target group (15 patients), the latter being associated with a cardiovascular risk increase of 2. Ten patients exhibited a LDLc > 100 mg/dl with Fibrinogen > 350 mg/dl and PCR us > 2.6 mg/l, 60% of these patients presented evidence of induced ischemia, and consequently were submitted to hemodynamia and all were suffering from coronary artery disease. Conclusion: In patients with 2 or more risk factors for..
Disciplinas: Medicina
Palabras clave: Diagnóstico,
Metabolismo y nutrición,
Sistema cardiovascular,
Aterosclerosis,
Proteína C reactiva,
Factores de riesgo,
Enfermedad coronaria
Keyword: Medicine,
Cardiovascular system,
Diagnosis,
Metabolism and nutrition,
Atherosclerosis,
C reactive protein,
Risk factors,
Coronary artery disease
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