| Revista: | Archivos venezolanos de farmacología y terapeútica |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000393046 |
| ISSN: | 0798-0264 |
| Autores: | Trejo, E1 Borges, A1 González de Alfonzo, R1 Lippo de Becemberg, I1 Alfonzo, M.J1 |
| Instituciones: | 1Universidad Central de Venezuela, Facultad de Medicina, Maracay, Aragua. Venezuela |
| Año: | 2012 |
| Volumen: | 31 |
| Número: | 1 |
| País: | Venezuela |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Analítico, descriptivo |
| Resumen en español | El escorpionismo en Venezuela es un problema actual de salud pública producido por las especies de Tityus discrepans (TD) y Tityus zulianus (TZ). Los pacientes que presentan escorpionismo producido por TD desarrollan trastornos gastrointestinales y pancreáticos mientras que los afectados por TZ presentan una alta mortalidad y muestran una sintomatología relacionada a desordenes cardiopulmonares, los cuales parecen estar asociados a niveles elevados de las catecolaminas plasmáticas. Esta clínica diferente parece estar asociada a una composición distinta de toxinas de dichos venenos, lo cual ha sido previamente demostrado. En un intento de mimetizar o reproducir el escorpionismo en humanos se han realizado estudios toxinológicos con los venenos de TZ y TD utilizando varios biomodelos como son ratones y carneros anestesiados |
| Resumen en inglés | Venezuelan scorpion envenomation is a public health problem produced by Tityus discrepans (TD) and Tityus zulianus (TZ) species. Patients-envenomend by TD developed gastrointestinal and pancreatic disorders and scorpion accidents involving TZ are associated with high mortality rate, which showed cardiopulmonary clinical disorders may be associated to the high levels of plasma catecholamines levels. This distinctive clinical output seems to be associated to a toxin repertoire diversity, which has been previously demonstrated. Trying to mimic the human-envenomation, some toxinological studies have been performed using TD and TZ venoms in several biomodels such as mice and anesthetized rams. The purpose of this study was to evaluate, in vivo using biomodels (mice), the role of autonomic nervous system (sympathetic) stimulation producing some of the clinical signs, via the catecholamines release, on the patho-physiology of the TZ and TD induced envenomation. Thus, a clinical signs here reported during a period of 1 hr, after a single intra-peritoneal injection of sub-lethal doses of TZ or TD venom, which are related with diarrhea, diaphoresis, intense salivation, dehydratation, dyspnea and spasticity in hind limbs. However, these animals did not exhibit vomiting, which is the most frequent human-envenomed TD patients. All animals inoculated with (TD or TZ) venoms developed diarrhea being more pronounced in TD group. Diaphoresis, sialorrhea and dehydratation were mainly observed in TD group. Dyspnea and the hind limb spasticity were only developed in TZ mice. These clinical manifestations (diarrhea, sialorrhea, dehydratation and intense salivation) are related to an activation of autonomic nervous system, via an intense release of their related neurotransmitters. Thus, autonomic stimulation (sympathetic) was evaluated following the catecholamine (Nor-Epinephrine)(NE) plasma levels in a function of enven |
| Disciplinas: | Medicina, Biología |
| Palabras clave: | Medicina experimental, Salud pública, Quelicerados, Escorpiones, Veneno, Venezuela, Tityus zulianus, Tityus discrepans |
| Keyword: | Medicine, Biology, Experimental medicine, Pharmacology, Public health, Chelicerata, Scorpions, Venom, Venezuela, Tityus zulianus, Tityus discrepans |
| Texto completo: | Texto completo (Ver PDF) |
