| Journal: | The journal of venomous animals and toxins including tropical diseases |
| Database: | PERIÓDICA |
| System number: | 000298951 |
| ISSN: | 1678-9199 |
| Authors: | Ferreira-Junior, R.S1 Nascimento, N2 Couto, R3 Alves, J.B Meira, D.A Barraviera, B |
| Institutions: | 1Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina de Botucatu, Botucatu, Sao Paulo. Brasil 2Comissao Nacional de Energia Nuclear, Instituto de Pesquisas Energeticas e Nucleares, Sao Paulo. Brasil 3Universidade Estadual Paulista "Julio de Mesquita Filho", Faculdade de Medicina Veterinaria e Zootecnia, Botucatu, Sao Paulo. Brasil |
| Year: | 2006 |
| Volumen: | 12 |
| Number: | 4 |
| Pages: | 620-631 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Laboratory profile of young ovines was studied in order to evaluate and compare their antiserum production from natural and Cobalt-60 irradiated Crotalus durissus terrificus (C.d.t.) venoms. The parameters analyzed included complete blood count, and urea, creatinine, aspartate aminotransferase, total proteins, albumin and globulin serum measurements. Three groups of six animals each were used. Group 1 (G1) received natural C.d.t. venom; Group 2 (G2) received irradiated C.d.t. venom; and Group 3 (G3) was used as control and did not receive venom, only adjuvants, using seven venom inoculations. During the experimental period, animals were fortnightly weighed. According to clinical and weight evaluation, sheep in post-weaning phase showed no changes in their physiological profiles but had excellent weight gain. The parameters analyzed were not statistically different (p<5%) among the groups tested. The hyperimmunization process was successfully accomplished with the production of specific antibodies against Crotalus durissus terrificus venom. Results bring a new possibility of utilizing ovines in the commercial production of anticrotalic serum, which may be used to treat human and animal envenomation. Its production cost may be reduced by subsequent use of hyperimmunized sheep for human consumption |
| Disciplines: | Medicina veterinaria y zootecnia |
| Keyword: | Ovinos y caprinos, Inmunología, Veneno de víbora, Hiperinmunización, Producción de antisuero, Ovejas, Crotalus durissus terrificus, Viperidae |
| Keyword: | Veterinary medicine and animal husbandry, Sheep and goats, Immunology, Snake venom, Hyperimmunization, Antiserum production, Sheep, Crotalus durissus terrificus, Viperidae |
| Full text: | Texto completo (Ver HTML) |
