| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290992 |
| ISSN: | 1413-8670 |
| Authors: | Nogueira, Keite da Silva1 Nogueira, Keite da Silva2 Higuti, Ilma Hiroko Nascimento, Aguinaldo Jose do3 Terasawa, Larissa Bail Oliveira, Simone de Matos, Adriana Pereira4 Souza, Helena Aguilar Peres Homem de Mello de Cogo, Laura Lucia Dalla Costa, Libera Maria |
| Institutions: | 1Universidade Federal do Parana, Laboratorio de Bacteriologia, Curitiba, Parana. Brasil 2Universidade Federal do Parana, Departamento de Patologia Basica, Curitiba, Parana. Brasil 3Universidade Federal do Parana, Departamento de Bioquimica, Curitiba, Parana. Brasil 4Pontificia Universidade Catolica do Parana, Hospital Cajuru, Curitiba, Parana. Brasil |
| Year: | 2006 |
| Season: | Dic |
| Volumen: | 10 |
| Number: | 6 |
| Pages: | 390-395 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Caso clínico |
| English abstract | Production of extended-spectrum beta-lactamases (ESBL) by enterobacteria is an important resistance mechanism against antimicrobial beta-lactamics. We tested 498 bacterial strains isolated from two tertiary-care teaching hospitals for ESBL production, using screening breakpoints for aztreonam and third generation cephalosporins, according to CLSI recommendations. Among these isolates, 155 were positive for the ESBL screening test, and 121 (78%) were confirmed by the clavulanic acid combination disk method. We found a high frequency of ESBL (24%) among Enterobacteriaceae, with a frequency of 57.4% for Klebsiella pneumoniae, 21.4% for Klebsiella oxytoca, and 7.2% for E. coli. In other members of Enterobacteriaceae, non-Klebsiella and non-E. coli, the prevalence was 21.6%. Ceftriaxone and cefotaxime showed a higher sensitivity in the screening test (99.2%) when compared to ceftazidime, aztreonam and cefpodoxime. However, cefotaxime/cefotaxime plus clavulanic acid showed a higher sensitivity in the confirmatory test (96.7%) |
| Disciplines: | Biología, Química, Medicina |
| Keyword: | Bacterias, Bioquímica, Hospitales, Espectro, Beta-lactamasa, Enterobacteriaceae, Klebsiella pneumoniae, Klebsiella oxytoca |
| Keyword: | Biology, Chemistry, Medicine, Bacteria, Biochemistry, Hospitals, Spectrum, Beta-lactamase, Enterobacteriaceae, Klebsiella pneumoniae, Klebsiella oxytoca |
| Full text: | Texto completo (Ver HTML) |
