| Journal: | The brazilian journal of infectious diseases |
| Database: | PERIÓDICA |
| System number: | 000290999 |
| ISSN: | 1413-8670 |
| Authors: | Pinheiro, Valeria Goes Ferreira1 Ramos, Lysiane M.A Monteiro, Helena S.A Barroso, Elizabeth Clara Bushen, Oluma Y2 Facanha, Monica Cardoso Peloquin, Charles A3 Guerrant, Richard L Lima, Aldo A.M |
| Institutions: | 1Universidade Federal do Ceara, Faculdade de Medicina, Fortaleza, Ceara. Brasil 2University of Virginia, Center for Global Health, Charlottesville, Virginia. Estados Unidos de América 3National Jewish Medical and Research Center, Infectious Disease Pharmacokinetics Laboratory, Denver, Colorado. Estados Unidos de América |
| Year: | 2006 |
| Season: | Dic |
| Volumen: | 10 |
| Number: | 6 |
| Pages: | 374-379 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Low antimycobacterial drug concentrations have been observed in tuberculosis (TB) patients under treatment. The lactulose/mannitol urinary excretion test (L/M), normally used to measure intestinal permeability, may be useful to assess drug absorption. The objective of this research was to study intestinal absorptive function and bioavailability of rifampin and isoniazid in TB patients. A cross sectional study was done with 41 patients and 28 healthy controls, using the L/M test. The bioavailabilities of rifampin (R) and isoniazid (H) were evaluated in 18 patients receiving full doses. Urinary excretion of mannitol and lactulose, measured by HPLC, was significantly lower in TB patients. The serum concentrations of the drugs were below the expected range for R (8-24 mcg/mL) or H (3-6 mcg/mL) in 16/18 patients. Analyzing the drugs individually, 12/18 patients had low serum concentrations of R, 13/18 for H and 8/18 for both drugs. We suggest that there is a decrease in the functional absorptive area of the intestine in TB patients, which would explain the reduced serum concentrations of antituberculosis drugs. There is a need for new approaches to improve drug bioavailability in TB patients |
| Disciplines: | Medicina |
| Keyword: | Fisiología humana, Gastroenterología, Neumología, Tuberculosis pulmonar, Permeabilidad intestinal, Malabsorción, Rifampicina, Isoniacida, Resistencia, Mycobacterium tuberculosis |
| Keyword: | Medicine, Gastroenterology, Human physiology, Pneumology, Pulmonary tuberculosis, Intestinal permeability, Intestinal malabsorption, Rifampin, Isoniazid, Resistance, Mycobacterium tuberculosis |
| Full text: | Texto completo (Ver HTML) |
