| Journal: | Revista mexicana de urología |
| Database: | PERIÓDICA |
| System number: | 000388000 |
| ISSN: | 0185-4542 |
| Authors: | Linden Castro, E1 Pelayo Nieto, M1 Alias Melgar, A1 Perez Grovas, D1 Ramírez Pedraza, J1 Morales Covarrubias, J1 Cortez Betancourt, R1 Carreño de la Rosa, F1 Neave Sánchez, E1 |
| Institutions: | 1Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado, Centro Médico Nacional 20 de Noviembre, México, Distrito Federal. México |
| Year: | 2014 |
| Volumen: | 74 |
| Number: | 5 |
| Pages: | 275-280 |
| Country: | México |
| Language: | Español |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| Spanish abstract | Objetivo: Describir la relación entre la obesidad y la agresividad en cáncer de próstata (CaP) en población mexicana. Materiales y métodos: Se obtuvieron datos de manera retrospectiva del expediente electrónico de 167 pacientes de CaP. Se agruparon por índice de masa corporal (IMC), edad, Gleason, estadio clínico (EC), y por grupos de acuerdo a la clasificación D’Amico. Se correlacionaron las variables (IMC, antígeno prostático específico [PSA], EC, Gleason) y se analizaron usando modelos estadísticos. Resultados: Se analizaron 167 pacientes con CaP con una edad promedio de 69.4 anos, PSA ˜ pre-biopsia promedio de 25.36 ng/ml, el 45, el 22.75 y el 5.3% presentaron sobrepeso, obesidad grado I y obesidad grado II, respectivamente; el 25.7% dentro de su peso. Gleason 6: 41.91%, de los que el 47.9% se clasificó como cT1c. El 11.37, el 23.95 y el 64.67% fueron clasificados por D’Amico como riesgo bajo, intermedio y alto, respectivamente. Aquellos con un IMC > 25 kg/m2 presentaron un mayor riesgo de CaP de alto riesgo (OR: 1.027), p = 0.46, y aquellos con un IMC > 25 kg/m2 presentaron mayor riesgo de Gleason 8-10 (OR: 1.310), p = 0.23. Encontramos una relación entre el IMC > 25 kg/m2 y PSA < 20 ng/ml (OR: 1.14), p = 0.36. Así, la relación de IMC > 25 kg/m2 y PSA > 20 ng/ml se encontró una asociación negativa (OR: 0.87), p = 0.35. Identificamos que realmente no existe una diferencia significativa entre IMC y EC cT (OR: 0.89), p = 0.15. Conclusiones: Los pacientes obesos tienen un riesgo mayor de CaP agresivo. Estos presentaron un PSA más bajo, y los pacientes con sobrepeso y obesidad presentaron un Gleason mayor |
| English abstract | Aims: To describe the relation between obesity and prostate cancer (CaP) aggressiveness in a Mexican population. Methods: Data was collected retrospectively from the electronic medical files of 167 patients with CaP. They were grouped according to body mass index (BMI), age, Gleason score, clinical stage, and D’Amico classification. The variables were correlated (BMI, prostate-specific antigen [PSA], clinical stage, Gleason score) and were analyzed using statistical models. Results: A total of 167 patients with CaP were studied. The mean age was 69.4 years and mean pre-biopsy PSA was 25.36 ng/m. Overweight was present as Grade I and Grade II obesity in 45% and 22.75% of the patients, respectively, and 25.7% were within their normal weight range. A total of 41.9% of the patients had a Gleason score of 6 and 47.9% of the tumors were classified as stage cT1c. According to the D’Amico classification, 11.37% of the patients were considered at low risk for aggressive CaP, 23.95% at intermediate risk, and 64.67% were at high risk. Those patients with a BMI > 25 kg/m2 presented with a greater risk for high-risk CaP (OR 1.027; P = .46) and those with a BMI > 25 kg/m2 had a greater risk for a Gleason score of 8-10 (OR 1.310; P = .23). We identified a relation between BMI > 25 kg/m2 and PSA < 20 ng/mL (OR 1.14; P = .36) and a negative association between BMI > 25 kg/m2 and PSA > 20 ng/mL (OR 0.87; P = .35). No significant difference was found between BMI and clinical stage (OR 0.89; P = 0.15). Conclusions: Obese patients are at a higher risk for aggressive CaP; they presented with a lower PSA and the overweight and obese patients had a higher Gleason score. These data will enable us to make better preventive and therapeutic decisions in overweight and obese men with CaP |
| Disciplines: | Medicina |
| Keyword: | Nefrología, Oncología, Cáncer, Próstata, Alto riesgo, Obesidad, Indice de masa corporal, Puntaje de Gleason |
| Keyword: | Medicine, Nephrology, Oncology, Cancer, Prostate, High risk, Obesity, Body mass index, Gleason score |
| Full text: | Texto completo (Ver PDF) |
