| Journal: | Revista mexicana de ciencias farmacéuticas |
| Database: | PERIÓDICA |
| System number: | 000392716 |
| ISSN: | 1870-0195 |
| Authors: | Palacios Rosas, Erika1 Orozco Alarcón, Angela2 |
| Institutions: | 1Universidad de las Américas, Escuela de Ciencias, Cholula, Puebla. México 2Universidad Autónoma de Madrid, Facultad de Medicina, Madrid. España |
| Year: | 2014 |
| Season: | Oct-Dic |
| Volumen: | 45 |
| Number: | 4 |
| Pages: | 41-46 |
| Country: | México |
| Language: | Español |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| Spanish abstract | Se evaluó el papel de interleuquina-1β(IL-1β) en la disfunción endotelial asociada a la diabetes mellitus mediante la técnica de reactividad vascular en microvasos mesentéricos de rata Sprague-Dawley. Se demostró que la incubación de los microvasos con IL-1β produce disfunción endotelial de manera concentración-dependiente. El tratamiento de los microvasos con el antagonista del receptor de IL-1, anakinra (AK), produjo un bloqueo concentración dependiente de la disfunción causada por IL-1β. Se estudió la función endotelial en un modelo de diabetes-1, donde se produjo un deterioro de la relajación transcurridas dos semanas de evolución de la enfermedad, la función endotelial se restauró parcialmente mediante el tratamiento con AK |
| English abstract | The role of interleukin-1β (IL-1β) on endothelial dysfunction associated with diabetes mellitus was evaluated by the technique of vascular reactivity in mesenteric microvessel of Sprague-Dawley rat. It was shown that the mere increase of D-glucose is not sufficient to induce an impairment in endothelium-dependent relaxation. However, pre-incubation with IL-1β produced endothelial dysfunction concentration-dependently, enhanced by increasing concentrations of D-glucose. Treatment of microvessel with the receptor antagonist IL-1, anakinra (AK), produced a concentration-dependent blocking dysfunction caused by IL-1β. Endothelial function was studied in a model of diabetes-1, where there was a deterioration of the relaxation elapsed two weeks of disease progression, endothelial function was partially restored by treatment with AK |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Medicina experimental, Metabolismo y nutrición, Disfunción endotelial, Diabetes mellitus, Interleuquina, Reactividad vascular, Animales de laboratorio, Ratas |
| Keyword: | Medicine, Experimental medicine, Metabolism and nutrition, Pharmacology, Endothelial dysfunction, Diabetes mellitus, Interleukins, Laboratory animals, Rats |
| Full text: | Texto completo (Ver HTML) |
