Menopausal Women Have Hypofibrinolysis Even in Subclinical Stage of Atherosclerosis
Document title: Menopausal Women Have Hypofibrinolysis Even in Subclinical Stage of Atherosclerosis
Journal: Revista de investigación clínica
Database: PERIÓDICA
System number: 000390746
ISSN: 0034-8376
Authors: 1
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Institutions: 1Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, México, Distrito Federal. México
2Instituto Mexicano del Seguro Social, Coordinación de Investigación en Salud, México, Distrito Federal. México
3Instituto Politécnico Nacional, Escuela Nacional de Ciencias Biológicas, México, Distrito Federal. México
Year:
Season: Mar-Abr
Volumen: 67
Number: 2
Pages: 122-129
Country: México
Language: Inglés
Document type: Estadística o encuesta
Approach: Analítico
English abstract PAI-1 is the main inhibitor of fibrinolysis. Increase in PAI-1 levels has been associated with the risk of coronary disease; however, there are few studies on the relationship between subclinical atherosclerosis and PAI-1 levels. Objective: The aim of this study was to analyze the relationship between PAI-1 level and carotid intima-media thickness in premenopausal and postmenopausal women without apparent cardiovascular disease. Material and Methods: A cross-sectional study was conducted in 142 women aged 45 to 60 years with no history of cardiovascular disease. Anthropometric and laboratory measurements were performed, including PAI-1 levels. All participants underwent a B-Mode ultrasound to measure intima-media thickness. Subclinical atherosclerosis was considered when intima-media thickness was ≥ 0.7 mm and/or an atheromatous plaque was observed. Results: Postmenopausal women had greater intima-media thickness than premenopausal women (0.688 ± 0.129 vs. 0.621 ± 0.113 mm; p < 0.05). Compared to women with normal intima-media thickness, women with subclinical atherosclerosis had higher PAI-1 levels (23.2 ± 13.7 vs. 30.4 ± 20.7 ng/ml; p < 0.05). In all participants, intima-media thickness correlated with PAI-1 (r = 0.302; p = 0.01) and with age (r = 0.358; p = 0001). Conclusions: An increase in intima-media thickness was observed in postmenopausal women compared with premenopausal women. Asymptomatic women with increased intima-media thickness had higher PAI-1 levels. These findings suggest that fibrinolytic activity is low in the subclinical stage of atherosclerosis
Disciplines: Medicina
Keyword: Ginecología y obstetricia,
Sistema cardiovascular,
Aterosclerosis,
Fibrinólisis,
Menopausia,
Carótida,
Inhibidor del activador de plasminógeno,
Espesor
Keyword: Medicine,
Cardiovascular system,
Gynecology and obstetrics,
Atherosclerosis,
Fibrinolysis,
Menopause,
Carotid artery,
Thickness,
Plasminogen activator inhibitor
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