Uniparental ancestry markers in Chilean populations



Document title: Uniparental ancestry markers in Chilean populations
Journal: Genetics and molecular biology
Database: PERIÓDICA
System number: 000401310
ISSN: 1415-4757
Authors: 1
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Institutions: 1Universidade Federal do Rio de Janeiro, Instituto de Biologia, Rio de Janeiro. Brasil
2Universidad de Chile, Hospital Clínico, Santiago de Chile. Brasil
3Hospital Regional de Valdivia, Valdivia. Chile
4Hospital Puerto Montt, Servicio de Neonatología, Puerto Montt. Chile
5Hospital del Salvador, Santiago de Chile. Chile
6Hospital Clínico San Borja Arriarán, Santiago de Chile. Chile
7Hospital de Cauquenes, Cauquenes, Linares. Chile
8Hospital Curicó, Curicó. Chile
9Fundacao Oswaldo Cruz, Instituto Oswaldo Cruz, Rio de Janeiro. Brasil
Year:
Season: Dic
Volumen: 39
Number: 4
Pages: 573-579
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico
English abstract The presence of Native Americans, Europeans, and Africans has led to the development of a multi-ethnic, admixed population in Chile. This study aimed to contribute to the characterization of the uniparental genetic structure of three Chilean regions. Newborns from seven hospitals in Independencia, Providencia, Santiago, Curicó, Cauquenes, Valdívia, and Puerto Montt communes, belonging to the Chilean regions of Santiago, Maule, and Los Lagos, were studied. The presence of Native American mitochondrial DNA (mtDNA) haplogroups and two markers present in the non-recombinant region of the Y chromosome, DYS199 and DYS287, indicative of Native American and African ancestry, respectively, was determined. A high Native American matrilineal contribution and a low Native American and African patrilineal contributions were found in all three studied regions. As previously found in Chilean admixed populations, the Native American matrilineal contribution was lower in Santiago than in the other studied regions. However, there was an unexpectedly higher contribution of Native American ancestry in one of the studied communes in Santiago, probably due to the high rate of immigration from other regions of the country. The population genetic sub-structure we detected in Santiago using few uniparental markers requires further confirmation, owing to possible stratification for autosomal and X-chromosome markers
Disciplines: Medicina
Keyword: Genética,
Genética de poblaciones,
Marcadores genéticos,
Marcadores uniparentales,
ADN mitocondrial,
Cromosoma Y,
Ascendencia
Keyword: Medicine,
Genetics,
Population genetics,
Genetic markers,
Uniparental markers,
Mitochondrial DNA,
Chromosome Y,
Ancestry
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