| Journal: | Ecletica quimica |
| Database: | PERIÓDICA |
| System number: | 000340622 |
| ISSN: | 0100-4670 |
| Authors: | Santos, Thiago de Almeida Drumond dos1 Costa, Diego Oliveira da1 Pita, Samuel Silva da Rocha2 Semaan, Felipe Silva1 |
| Institutions: | 1Universidade Federal Fluminense, Instituto de Quimica, Niteroi, Rio de Janeiro. Brasil 2Universidade Federal do Rio de Janeiro, Instituto de Biofisica Carlos Chagas Filho, Rio de Janeiro. Brasil |
| Year: | 2010 |
| Season: | Oct-Dic |
| Volumen: | 35 |
| Number: | 4 |
| Pages: | 81-86 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | The combination of two low-cost classical procedures based on titrimetric techniques is presented for the determination of pyridoxine hydrochloride in pharmaceuticals samples. Initially some experiments were carried out aiming to determine both pKa1 and pKa2 values, being those compared to values of literature and theoretical procedures. Commercial samples containing pyridoxine hydrochloride were electrochemically analysed by exploiting their acid-base and precipitation reactions. Potentiometric titrations accomplished the reaction between the ionizable hydrogens present in pyridoxine hydrochloride, being NaOH used as titrant; while the conductimetric method was based on the chemical precipitation between the chloride of pyridoxine hydrochloride molecule and Ag+ ions from de silver nitrate, changing the conductivity of the solution. Both methods were applied to the same commercial samples leading to concordant results when compared by statistical tests (95 and 98% confidence levels). Recoveries ranging from 99.0 to 108.1% were observed, showing no significant interference on the results |
| Disciplines: | Química |
| Keyword: | Química analítica, Química farmacéutica, Fármacos, Clorhidrato de piridoxina, Valoración potenciométrica, valoración conductimétrica |
| Keyword: | Chemistry, Analytical chemistry, Medicinal chemistry, Pharmaceuticals, Pyridoxine hydrochloride, Potentiometric titration, Conductimetric titration |
| Full text: | Texto completo (Ver PDF) |
