| Journal: | Brazilian journal of physics |
| Database: | PERIÓDICA |
| System number: | 000392492 |
| ISSN: | 0103-9733 |
| Authors: | Freitas, Maria Camila Pruper de1 Figueiredo-Neto, Antonio Martins2 Giampaoli, Viviane3 Aubin, Elisete da Conceicao Quintaneiro3 Barbosa, Milena Maria de Araujo Lima1 Damasceno, Nagila Raquel Teixeira1 |
| Institutions: | 1Universidade de Sao Paulo, Escola de Saude Publica, Sao Paulo. Brasil 2Universidade de Sao Paulo, Instituto de Fisica, Sao Paulo. Brasil 3Universidade de Sao Paulo, Instituto de Matematica e Estatistica, Sao Paulo. Brasil |
| Year: | 2016 |
| Season: | Abr |
| Volumen: | 46 |
| Number: | 2 |
| Pages: | 163-169 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, analítico |
| English abstract | The great atherogenic potential of oxidized lowdensity lipoprotein has been widely described in the literature. The objective of this study was to investigate whether the state of oxidized low-density lipoprotein in human plasma measured by the Z-scan technique has an association with different cardiometabolic biomarkers. Total cholesterol, highdensity lipoprotein cholesterol, triacylglycerols, apolipoprotein A–I and apolipoprotein B, paraoxonase-1, and glucose were analyzed using standard commercial kits, and lowdensity lipoprotein cholesterol was estimated using the Friedewald equation. A sandwich enzyme-linked immunosorbent assay was used to detect electronegative low-density lipoprotein. Low-density lipoprotein and high-density lipoprotein sizes were determined by Lipoprint® system. The Z-scan technique was used to measure the non-linear optical response of low-density lipoprotein solution. Principal component analysis and correlations were used respectively to resize the data from the sample and test association between the θ parameter, measured with the Z-scan technique, and the principal component. A total of 63 individuals, from both sexes, with mean age 52 years (±11), being overweight and having high levels of total cholesterol and low levels of high-density lipoprotein cholesterol, were enrolled in this study. A positive correlation between the θ parameter and more anti-atherogenic pattern for cardiometabolic biomarkers together with a negative correlation for an atherogenic pattern was found. Regarding the parameters related with an atherogenic low-density lipoprotein profile, the θ parameter was negatively correlated with a more atherogenic pattern. By using Z-scan measurements, we were able to find an association between oxidized low-density lipoprotein state and multiple cardiometabolic biomarkers in samples from individuals with different cardiovascular risk factors |
| Disciplines: | Física y astronomía, Medicina |
| Keyword: | Física de materia condensada, Diagnóstico, Sistema cardiovascular, Enfermedades cardiovasculares, Lipoproteínas de baja densidad, Biomarcadores, Técnica Z-scan |
| Keyword: | Physics and astronomy, Medicine, Condensed matter physics, Cardiovascular system, Diagnosis, Cardiovascular diseases, Low density lipoproteins, Biomarkers, Z-scan technique |
| Full text: | Texto completo (Ver PDF) |
