Do intrauterine growth restriction and overweight at primary school age increase the risk of elevated body mass index in young adults?
Document title: Do intrauterine growth restriction and overweight at primary school age increase the risk of elevated body mass index in young adults?
Journal: Brazilian journal of medical and biological research
Database: PERIÓDICA
System number: 000351878
ISSN: 0100-879X
Authors: 1
2
3
1
4
5
5
5
Institutions: 1Universidade Federal do Maranhao, Departamento de Saude Publica, Sao Luis, Maranhao. Brasil
2Faculdade de Medicina de Marilia, Marilia, Sao Paulo. Brasil
3Universidade de Sao Paulo, Faculdade de Medicina de Ribeirao Preto, Ribeirao Preto, Sao Paulo. Brasil
4Universidade Federal de Santa Maria, Centro de Ciencias da Saude, Santa Maria, Rio Grande do Sul. Brasil
5Universidade Federal do Rio Grande do Sul, Faculdade de Medicina, Porto Alegre, Rio Grande do Sul. Brasil
Year:
Season: Sep
Volumen: 40
Number: 9
Pages: 1237-1243
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Obesity is one of the rising public health problems characterized as a risk factor for many chronic diseases in adulthood. Early life events such as intrauterine growth restriction, as well as life style, are associated with an increased prevalence of this disease. The present study was performed to determine if intrauterine growth restriction interacts with overweight at primary school age to affect body mass index (BMI) in young adults. From June 1, 1978 to May 31, 1979, 6827 singleton liveborns from Ribeirão Preto, São Paulo State, Brazil, corresponding to 98% of all births at the 8 maternity hospitals, were examined and their mothers were interviewed. Samples from the initial cohort were examined again at primary school age (8 to 11 years of age) and at the time of military service (18 years of age). There were 519 male individuals with complete measurements taken in the three surveys. Intrauterine growth-restricted individuals had a BMI 0.68 kg/m 2 lower than that of individuals who were not restricted (95%CI = -1.34 to -0.03) and overweight at primary school age showed a positive and strong effect on BMI at 18 years of age (coefficient 5.03, 95%CI = 4.27 to 5.79). However, the increase in BMI was much higher - 6.90 kg/m 2 - when the conscript had been born with intrauterine growth restriction and presented overweight at primary school age (95%CI = 4.55 to 9.26). These findings indicate that the effect of intrauterine growth restriction on BMI at 18 years of age is modified by later weight gain during school age
Disciplines: Medicina
Keyword: Pediatría,
Salud pública,
Estudios de cohorte,
Crecimiento intrauterino,
Obesidad,
Sobrepeso,
Indice de masa corporal,
Adultos
Keyword: Medicine,
Pediatrics,
Public health,
Cohort studies,
Intrauterine growth,
Obesity,
Overweight,
Body mass index,
Adults
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