Efficacy of electroconvulsive therapy augmentation for partial response to clozapine: a pilot randomized ECT – sham controlled trial
Document title: Efficacy of electroconvulsive therapy augmentation for partial response to clozapine: a pilot randomized ECT – sham controlled trial
Journal: Archives of clinical psychiatry
Database: PERIÓDICA
System number: 000407888
Authors: 1
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3
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Institutions: 1Universidade de Sao Paulo, Faculdade de Medicina, Sao Paulo. Brasil
2Santa Casa de Sao Paulo, Escola de Medicina, Sao Paulo. Brasil
3Universidade de Sao Paulo, Escola de Enfermagem, Sao Paulo. Brasil
Year:
Season: Mar-Abr
Volumen: 44
Number: 2
Pages: 45-50
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Analítico, descriptivo
English abstract Thirty percent of schizophrenia patients are treatment-resistant. Objective This is a single-blinded sham-controlled trial to assess the efficacy of electroconvulsive therapy (ECT) as augmentation strategy in patients with clozapine-resistant schizophrenia. Methods Twenty three subjects were randomly assigned to 12 sessions of ECT (N = 13) or placebo (Sham ECT) (N = 10). The primary outcome was improvement on psychotic symptoms as measured by the mean reduction of the PANSS positive subscale. The assessments were performed by blind raters. Results At baseline both groups were similar, except for negative and total symptoms of the PANSS, which were higher in the Sham group. At the endpoint both groups had a significant decrease from basal score. In the ECT group the PANSS total score decreased 8.78%, from 81.23 to 74.75 (p = 0.042), while the positive subscale had a mean reduction of 19% (19.31 to 16.17, p = 0.006). In the Sham group, the mean reduction of PANSS total score was 15.27% (96.80 to 87.43; p = 0.036), and the PANSS positive subscale decreased 27.81% (22.90 to 19.14, p = 0.008). The CGI score in ECT group decreased 23.0% (5.23 to 4.17; p = 0.001) and decreased 24.31% in the Sham ECT group (5.80 to 4.86; p = 0.004). Discussion In this pilot study, we found no difference between the groups
Disciplines: Medicina
Keyword: Psiquiatría,
Terapéutica y rehabilitación,
Esquizofrenia,
Terapia electroconvulsiva,
Clozapina
Keyword: Medicine,
Psychiatry,
Therapeutics and rehabilitation,
Schizophrenia,
Electroconvulsive therapy,
Clozapine
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