The Use of Interferons in the Treatment of Pre-Invasive Cervical Neoplasias



Document title: The Use of Interferons in the Treatment of Pre-Invasive Cervical Neoplasias
Journal: ARBS. Annual review of biomedical sciences
Database: PERIÓDICA
System number: 000350439
ISSN: 1678-4618
Authors: 1
1
1
Institutions: 1Universidade Federal do Triangulo Mineiro, Instituto de Pesquisa em Oncologia, Uberaba, Minas Gerais. Brasil
Year:
Volumen: 13
Pages: 17-22
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract The evolution of cervical intraepithelial neoplasias (CINs) can lead to the development of cervical carcinomas and is closely tied to infection with human papillomavirus (HPV). Interferon (IFN)’s antitumor effects have a direct bearing on the proliferation or antigen composition of tumor cells, and act on specific tumor cells through immunomodulation. Moreover, some studies have indicated that type 1 IFN can have an antitumor effect by increasing levels of cytotoxic T cells, natural killer (NK) cells and dendritic cells (DCs). Immunotherapy with IFN has recently been used on cervical intraepithelial lesions and invasive cervical cancer with promising results. The objective of this mini-review is to discuss IFNs’ function, importance, and mechanism of action in the treatment of pre-malignant cervical neoplasias
Disciplines: Medicina
Keyword: Oncología,
Terapéutica,
Neoplasia intraepitelial,
Virus del papiloma humano,
Inmunoterapia,
Citocinas,
Interferón
Keyword: Medicine,
Oncology,
Therapeutics,
Intraepithelial neoplasm,
Human papillomavirus,
Immunotherapy,
Cytokines,
Interferon
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