Metastatic lymphoepithelioma-like hepatocellular carcinoma: a potential diagnostic pitfall and demonstration of Pd-l1 expression



Document title: Metastatic lymphoepithelioma-like hepatocellular carcinoma: a potential diagnostic pitfall and demonstration of Pd-l1 expression
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000406068
ISSN: 1665-2681
Authors: 1
2
2
3
1
Institutions: 1Icahn School of Medicine at Mount Sinai, Department of Pathology, Nueva York. Estados Unidos de América
2Lenox Hill Hospital, Department of Surgery, Houston, Texas. Estados Unidos de América
3Icahn School of Medicine at Mount Sinai, Department of Medicine, Nueva York. Estados Unidos de América
Year:
Season: Ene-Feb
Volumen: 16
Number: 1
Pages: 157-159
Country: México
Language: Inglés
Document type: Artículo
Approach: Caso clínico, analítico
English abstract Lymphoepithelioma-like hepatocellular carcinoma (LEL-HCC) is a rare primary hepatic neoplasm with female predominance and relatively good prognosis. We report a 73-year-old female with chronic hepatitis B who developed metastatic lesions 5 years after underwent resection for LEL-HCC. The metastatic lesions showed a spectrum of morphologic findings, which could be mistaken for other entities such as lymphoma, particularly in lesions with single-cell infiltrative pattern and abundant tumor-infiltrating lymphocytes. Immunohistochemical study to confirm the origin of the neoplastic cells is important to make the diagnosis. We also highlighted the clinicopathologic correlation and potential therapeutic implication of programmed death ligand-1 expression in LEL-HCC
Disciplines: Medicina
Keyword: Diagnóstico,
Gastroenterología,
Oncología,
Linfoepitelioma,
Carcinoma hepatocelular,
Hepatitis B,
Hepatitis crónica,
Metástasis,
PD-1,
Histología
Keyword: Medicine,
Diagnosis,
Gastroenterology,
Oncology,
Lymphoepithelioma,
Hepatocellular carcinoma,
Hepatitis B,
Chronic hepatitis,
Metastasis,
PD-1,
Histology
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