| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000409340 |
| ISSN: | 1665-2681 |
| Authors: | Saeedi, Ramesh1 Mojebi-Mogharar, Ali1 Sandhu, Supna K1 Dubland, Joshua A1 Ford, Jo-Ann1 Yousefi, Masoud1 Pudek, Morris1 Holmes, Daniel T1 Erb, Siegfried R1 Peter Kwan, Wing C1 Kendler, David L1 Yoshida, Eric M1 |
| Institutions: | 1University of British Columbia, Department of Medicine, Vancouver, Columbia Británica. Canadá |
| Year: | 2017 |
| Season: | Mar-Abr |
| Volumen: | 16 |
| Number: | 2 |
| Pages: | 207-214 |
| Country: | México |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Background. Patients with chronic hepatitis B virus (HBV) are often treated with nucleoside/nucleotide antiviral agents and metabolic bone toxicity is a possible concern. Objective. To determine the relationships between fibroblast growth factor 23 (FGF23), a phosphaturic hormone, bone mineral density (BMD), and bone biochemical abnormalities in these patients. Material and methods. This is a cross-sectional observational study comparing HBV-infected subjects treated for at least one year with tenofovir (TDF), lamuvidine (LVD), entacavir (ETV), or not treated (CON). Patients with abnormalities in either calcium (Ca), phosphate (PO4), intact parathyroid hormone (iPTH) or FGF23 were further evaluated with BMD by DXA. Results. No difference in liver enzymes or renal function seen among groups, but hypophosphatemia was seen in all groups with the highest incidence with TDF-treatment (14%). FGF 23 levels were found to be elevated in 11.1% of TDF patients, 2.77% amongst controls. No elevations were found in the LVD or ETV groups. Among a subset of subjects (FGF23, PO4, and/or Ca abnormalities) who underwent further evaluation, 67% had insufficient 25-OH vitamin D, and 30% had elevated 24 h urinary Ca or PO4 excretion. No patients with FGF23 abnormalities had urine abnormalities. 40% had low DXA Z-score (<-2) at spine or hip but there was no difference between control and antiviral treatment groups and the mean FRAX score was 2.33% for major osteoporotic fractures and 0.29% for hip fracture. Conclusion. Abnormalities in bone metabolism, particularly involving vitamin D insufficiency, in HBV-treated subjects were observed with a small increased likelihood in TDF treated patients |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Gastroenterología, Terapia antiviral, Hepatitis B, Factor de crecimiento de fibroblastos, Hipofosfatemia, Vitamina D, Metabolismo óseo |
| Keyword: | Medicine, Gastroenterology, Pharmacology, Antiviral therapy, Hepatitis B, Fibroblast growth factor, Hypophosphatemia, Vitamin D, Bone metabolism |
| Full text: | Texto completo (Ver PDF) |
