Effects of Interleukin-4 and Interleukin-12b Gene Polymorphisms on Hepatitis B Virus Vaccination



Document title: Effects of Interleukin-4 and Interleukin-12b Gene Polymorphisms on Hepatitis B Virus Vaccination
Journal: Annals of hepatology
Database: PERIÓDICA
System number: 000406026
ISSN: 1665-2681
Authors: 1
2
1
1
1
3
1
1
Institutions: 1Seoul National University, Boramae Medical Center, Seúl. Corea del Sur
2Seoul National University, College of Medicine, Seúl. Corea del Sur
3Gyeongsang National University, College of Medicine, Jinju. Corea del Sur
Year:
Season: Ene-Feb
Volumen: 16
Number: 1
Pages: 63-70
Country: México
Language: Inglés
Document type: Estadística o encuesta
Approach: Analítico
English abstract Approximately 10% of individuals do not respond to hepatitis B virus (HBV) vaccination, i.e. non-responders (NRs). We aimed to investigate the association of interleukin (IL)-4 and IL-12B gene polymorphisms with responsiveness to the HBV vaccine in Korean infants. Among 300 healthy infants (9-12 month), SNPs for the IL-4 gene (rs2243250, rs2070874, and rs2227284) and for the IL-12B gene (rs3213094 and rs17860508) were compared between subgroups in terms of the response to HBV vaccination. The percentages of NRs (< 10 mIU/mL), low-titer responders (LRs, 10-100 mIU/mL), and high-titer responders (HRs, ≥ 100 mIU/mL) were 20.3%, 37.7% and 42.0%, respectively. No SNPs differed in frequency between NRs and responders or between LRs and HRs. We divided the subjects into two groups according to the time interval from the 3rd dose of HBV vaccination to Ab quantification: > 6 months from the 3rd dose (n = 87) and ≤ 6 months from the 3rd dose (n = 213). In the ≤ 6 month subjects, rs2243250C and rs2227284G were significantly frequent in the lower-titer individuals (NRs + LR) than HRs (40.1 vs. 25.9%, p = 0.014 and 45.1 vs. 33.0%, p = 0.018, respectively), and the rs2243250C and rs2227284G frequencies were significantly different among the three subgroups (13.2 vs. 26.9 vs. 25.9%, p = 0.040 and 15.5 vs. 29.6 vs. 33.0%, p = 0.038, respectively). In conclusion, those results suggest that IL-4 gene polymorphisms may play a role in the response to the HBV vaccine in Korean infants
Disciplines: Medicina
Keyword: Gastroenterología,
Salud pública,
Genética,
Hepatitis B,
Vacunas,
Interleucina-12,
Interleucina-4,
Polimorfismo genético,
Corea
Keyword: Medicine,
Gastroenterology,
Public health,
Genetics,
Hepatitis B,
Vaccines,
Interleukin-12,
Interleukin-4,
Gene polymorphism,
Korea
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