| Journal: | Annals of hepatology |
| Database: | PERIÓDICA |
| System number: | 000409347 |
| ISSN: | 1665-2681 |
| Authors: | Karvellas, Constantine J1 Cardoso, Filipe S2 Senzolo, Marco3 Wells, Malcolm4 Alghanem, Mansour G4 Handou, Fayaz1 Kwapisz, Lukasz4 Kneteman, Norman M5 Marotta,Paul J4 Al-Judaibi, Bandar5 |
| Institutions: | 1University of Alberta, Division of Gastroenterology, Edmonton, Alberta. Canadá 2University of Alberta, Division of Critical Care Medicine, Edmonton, Alberta. Canadá 3Ospedale Universitario di Padova, Padova, Veneto. Italia 4Western University, London Health Sciences Centre, London, Ontario. Canadá 5University of Alberta, Division of Surgery, Edmonton, Alberta. Canadá |
| Year: | 2017 |
| Season: | Mar-Abr |
| Volumen: | 16 |
| Number: | 2 |
| Pages: | 236-246 |
| Country: | México |
| Language: | Inglés |
| Document type: | Estadística o encuesta |
| Approach: | Analítico |
| English abstract | To identify the impact of portal vein thrombosis (PVT) and associated medical and surgical factors on outcomes post liver transplant (LT). Material and methods. Two analyses were performed. Analysis One: cohort study of 505 consecutive patients who underwent LT (Alberta) between 01/2002-12/2012. PVT was identified in 61 (14%) patients. Analysis Two: cohort study of 144 consecutive PVT patients from two sites (Alberta and London) during the same period. Cox multivariable survival analysis was used to identify independent associations with post-LT mortality. Results. In Analysis One (Alberta), PVT was not associated with post-LT mortality (log rank p = 0.99). On adjusted analysis, complete/occlusive PVT was associated with increased mortality (Hazard Ratio (HR) 8.4, p < 0.001). In Analysis Two (Alberta and London), complete/occlusive PVT was associated with increased mortality only on unadjusted analysis (HR 3.7, p = 0.02). On adjusted analysis, Hepatitis C (HR 2.1, p = 0.03) and post-LT portal vein re-occlusion (HR 3.2, p = 0.01) were independently associated with increased mortality. Conclusion: Well-selected LT patients who had PVT prior to LT had similar post-LT outcomes to non-PVT LT recipients. Subgroups of PVT patients who did worse post-LT (complete/occlusive thrombosis pre-LT, Hepatitis C or post-LT portal vein re-occlusion) warrant closer evaluation in listing and management post-LT |
| Disciplines: | Medicina |
| Keyword: | Gastroenterología, Vena porta, Trombosis, Hígado, Trasplantes, Cirrosis, Anticoagulantes |
| Keyword: | Medicine, Gastroenterology, Portal vein, Thrombosis, Liver, Transplantation, Cirrhosis, Anticoagulation |
| Full text: | Texto completo (Ver PDF) |
