| Journal: | Anais da Academia Brasileira de Ciencias |
| Database: | PERIÓDICA |
| System number: | 000408994 |
| ISSN: | 0001-3765 |
| Authors: | Moura, Elviani B1 Petzhold, Silvia V3 Amaral, Augusto R4 Deboni, Luciane M2 Franca, Paulo H.C. de4 |
| Institutions: | 1Universidade da Regiao de Joinville, Departamento de Enfermagem, Joinville, Santa Catarina. Brasil 2Fundacao Pro-Rim, Joinville, Santa Catarina. Brasil 3Universidade da Regiao de Joinville, Departamento de Farmacia, Joinville, Santa Catarina. Brasil 4Universidade da Regiao de Joinville, Departamento de Medicina, Joinville, Santa Catarina. Brasil |
| Year: | 2017 |
| Season: | May |
| Volumen: | 89 |
| Pages: | 675-684 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Nota breve o noticia |
| Approach: | Caso clínico |
| English abstract | The BK virus (BKV) produces a subclinical kidney infection in immunocompetent individuals. However, viremia may occur in kidney transplant patients with ongoing immunosuppression. BKV-associated nephropathy (BKVN) has no specific treatment and is a leading cause of organ transplant loss. In this study, we evaluated the predisposition and the clinical impact of BKV replication in kidney transplant patients during post-transplant monitoring in a reference institution in Brazil. Demographic, clinical and laboratory data generated during routine outpatient follow-up were retrospectively collected. BK viremia was investigated using real-time polymerase chain reaction. Of the 553 participants, 7.4% (n = 41) presented BKV replication. Of these, 16 (39%) lost their kidney graft and interstitial nephritis was identified on kidney biopsy in 50% of the cases. Among the evaluated variables, only the use of the immunosuppressant mycophenolate sodium was identified as a risk factor for viremia (OR 7.96; 95% CI 2.35 to 26.98). The graft survival estimate in BKV-positive patients was significantly reduced (24.8% vs. 85.6%) after 10 years of transplantation. We concluded that defining predisposing factors remains an important challenge for the prevention and control of BKV activity following kidney transplantation, especially considering the development of BKVN and its strong effect on graft maintenance |
| Disciplines: | Biología, Medicina |
| Keyword: | Inmunología, Virus, Nefrología, Virus BK, Nefropatías, Trasplante renal, Viremia |
| Keyword: | Biology, Medicine, Immunology, Virus, Nephrology, BK virus, Nephropathies, Renal transplant, Viremia |
| Full text: | Texto completo (Ver PDF) |
