Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalies
Document title: Differences between NMRI and DBA/2J mice in the development of somites and susceptibility to methylnitrosourea-induced skeleton anomalies
Journal: Anais da Academia Brasileira de Ciencias
Database: PERIÓDICA
System number: 000408952
ISSN: 0001-3765
Authors: 1
2
Institutions: 1Charite University Medical School, Institute of Clinical Pharmacology and Toxicology, Berlín. Alemania
2Fundacao Oswaldo Cruz, Escola Nacional de Saude Publica, Rio de Janeiro. Brasil
Year:
Season: May
Volumen: 89
Pages: 635-647
Country: Brasil
Language: Inglés
Document type: Nota breve o noticia
Approach: Analítico, descriptivo
English abstract The development of DBA/2J mouse strain embryos is nearly 12 h - or 6 somite pairs - delayed as compared to the outbred NMRI mouse embryos of the same age on gestation days (GD) 8-12. To evaluate inter- strain differences in susceptibility to teratogens, dams were treated with methylnitrosourea (MNU, 5 mg/kg body weight i.p.) on defined gestation days (NMRI: GD 9, 9 1/2 or 10; DBA/2J: GD 10 or 10 1/2 ). Skeletal anomalies produced by MNU on both mouse strains varied with the GD of treatment. The pattern of anomalies produced by MNU on a given GD markedly differed between the two mouse strains, yet they were similar –with a few exceptions- when exposures at equivalent embryonic stages are compared. Findings from this study indicated that strain-dependent differences in the developmental stage of mouse embryos of the same gestational age occur, a possibility that has been often neglected when inter-strain differences in susceptibility to developmental toxicants are interpreted
Disciplines: Biología,
Química
Keyword: Mamíferos,
Reproducción y desarrollo,
Bioquímica,
Agentes alquilantes,
Desarrollo embrionario,
Cepas,
Ratones,
Anomalías estructurales,
Esqueleto,
Teratogenicidad
Keyword: Biology,
Chemistry,
Mammals,
Reproduction and development,
Biochemistry,
Alkylating agents,
Embryo development,
Structural anomalies,
Strains,
Mice,
Skeleton,
Teratogenicity
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