| Journal: | Anais brasileiros de dermatologia |
| Database: | PERIÓDICA |
| System number: | 000408846 |
| ISSN: | 0365-0596 |
| Authors: | Kartal, Demet1 Yasar, Mehmet2 Kartal, Levent2 Ozcan, Ibrahim2 Borlu, Murat1 |
| Institutions: | 1Erciyes University, Faculty of Medicine, Kayseri. Turquía 2Kayseri Education and Research Hospital, Department of Otorhinolaryngology, Kayseri. Turquía |
| Year: | 2017 |
| Season: | Mar-Abr |
| Volumen: | 92 |
| Number: | 2 |
| Pages: | 192-196 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Isotretinoin is a synthetic analog of vitamin A. Recent studies support a role for retinoic acid in the recovery of olfactory function following injury in mice. Objective: This study aimed at determining the effect of isotretinoin on olfactory function in patients who have acne and are otherwise healthy. Methods: Forty-five patients (aged 25-40 years) with acne were included in the study. All patients underwent a rhinological examination. Olfactory function was assessed by the Sniffin' Sticks Test. The test was assessed at baseline and in the third month of isotretinoin treatment. Results: Isotretinoin improved the performance of patients in the olfactory test. The SST score increased from 8.7±1.09 to 9.5±1.19 (p<0.001), prevalence of hyposmia decreased from 40% to 24% and normosmia increased from 60% to 75% (p=0.059). The percentage of patients whose olfactory function was categorized as "good" increased from 6% to 21.3%. This increase was statistically significant (p<0.05). Study limitations: Absence of a control group is one of the limitations of this study. Also, we did not evaluate patients with smell test after stopping isotretinoin treatment. Conclusion: We examined the effect of systemic isotretinoin on olfactory function. It can be concluded from the present investigation that isotretinoin therapy improves the sense of smell |
| Disciplines: | Medicina |
| Keyword: | Dermatología, Farmacología, Acné, Isotretinoína, Función olfatoria |
| Keyword: | Medicine, Dermatology, Pharmacology, Acne, Isotretinoin, Olfactory function |
| Full text: | Texto completo (Ver HTML) |
